Description: <p><b>Tanshinone IIA</b></p>
<p><b>Recommended Abbreviation:</b> Tan IIA</p>
<p><b>Alternative Names:</b> Tanshinone 2A, Tanshinone II A</p>
<p><b>Type:</b> Natural product / diterpene quinone / tanshinone</p>
<p><b>Source:</b> Major lipophilic bioactive constituent of the roots and rhizomes of <i>Salvia miltiorrhiza</i> Bunge (Danshen).</p>
<p><b>Function:</b> Tanshinone IIA has antioxidant, anti-inflammatory, neuroprotective, cardiovascular, metabolic, and anticancer activities. It modulates multiple signaling pathways involved in apoptosis, autophagy, proliferation, angiogenesis, inflammation, oxidative stress, and cellular metabolism.</p>
<p><b>Cancer:</b> Tanshinone IIA has extensive preclinical anticancer activity across multiple tumor types. Reported effects include proliferation ↓, migration/invasion ↓, angiogenesis ↓, apoptosis ↑, autophagy modulation, and suppression of oncogenic signaling including PI3K/AKT, MAPK, JAK/STAT3, and related pathways.</p>
<p><b>Alzheimer's Disease:</b> Tanshinone IIA has demonstrated neuroprotective and experimental anti-Alzheimer activity, including antioxidant and anti-inflammatory effects, protection against neuronal injury, and modulation of pathways associated with amyloid and neurodegenerative stress. Clinical evidence for Alzheimer's disease remains limited.</p>