tbResList Print — FS Flaxseed/Linseed

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Product

FS Flaxseed/Linseed
Description: <p>Flaxseed, Flaxseed refers to flax that is consumed by humans, while linseed is used when it is used for commercial purposes.<br>
-Buy whole raw flaxseed → grind it finely shortly before use. Whole seeds have their natural protective coat and therefore have better storage stability. Grinding disrupts that protection and improves bioavailability but simultaneously exposes ALA to oxygen.<br>
-even 10 g/day milled flaxseed significantly increased circulating total enterolignans and ALA in one randomized study<br>
-sprouts: At day 8, SDG was 6.3-fold higher and SECO 4.5-fold higher than in ungerminated seed. By day 10, total phenolics were ~5.6-fold higher and total flavonoids ~55-fold higher, with the highest measured antioxidant and antiproliferative activities.
-One study of 15 flax sprout varieties found SDG ranging from only 13.3 µg/g to 8,987 µg/g dry weight—a ~676-fold range.<br>
</p>

Pathway results for Effect on Cancer / Diseased Cells

NA, unassigned(tgid=0) ⓘ

Ingr↑, 1,   UFR↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   IAP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

Ki-67↓, 2,   TumCP↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

DHT↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 4,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   OS↑, 1,   Risk↓, 2,  
Total Targets: 20

Pathway results for Effect on Normal Cells

NA, unassigned(tgid=0) ⓘ

GPER↑, 1,   IPSS↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose?, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   QoL↑, 1,   toxicity↓, 2,  
Total Targets: 18

Research papers

Year Title Authors PMID Link Flag
2026Flax Lignans: From Biosynthetic Regulation to Biological ActivitiesCheng WangPMC13512916https://pmc.ncbi.nlm.nih.gov/articles/PMC13512916/0
2026Can flaxseed “milk” prevent anthracycline mediated cardiotoxicity in women with breast cancer (CANFLAX-BC)?Vibhuti AryaPMC12870242https://pmc.ncbi.nlm.nih.gov/articles/PMC12870242/0
2016The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1Guan-Yu Ren27849354https://pubmed.ncbi.nlm.nih.gov/27849354/0
2014Efficacy and safety of a flaxseed hull extract in the symptomatic management of benign prostatic hyperplasia: a parallel, randomized, double-blind, placebo-controlled, pilot studyRudy Simons25546379https://pubmed.ncbi.nlm.nih.gov/25546379/0
2014Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?Julie K Mason24869971https://pubmed.ncbi.nlm.nih.gov/24869971/0
2013Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancerMaria AzradPMC3624628https://pmc.ncbi.nlm.nih.gov/articles/PMC3624628/0
2009Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgeryWendy Demark-WahnefriedPMC2703189https://pmc.ncbi.nlm.nih.gov/articles/PMC2703189/0
2005The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseedAnneleen Kuijsten16317125https://pubmed.ncbi.nlm.nih.gov/16317125/0
2004Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigenWendy Demark-Wahnefried15134976https://pubmed.ncbi.nlm.nih.gov/15134976/0
2008Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasiaWei Zhang18358071https://pubmed.ncbi.nlm.nih.gov/18358071/0
2007Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivoMalin Bergman Jungeström17289903https://pubmed.ncbi.nlm.nih.gov/17289903/0