BF Bufalin
Description: <b>Bufalin</b> is a component from Chinese toad venom. Bufalin is classified as a cardiac glycoside, specifically a type of bufadienolide.<br>
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Pathways:<br>
-release of cytochrome c and subsequent activation of caspases<br>
-enhance the expression of death receptors<br>
-inhibit the PI3K/Akt/mTOR<br>
-modulate the MAPK/ERK pathway<br>
-inhibit NF-κB signaling<br>
-induce cell cycle arrest at different checkpoints (commonly G0/G1 or G2/M)<br>
-elevate intracellular ROS levels<br>
-interfere with the Wnt/β-catenin signaling pathway<br>
-modulate autophagy, a process that can either promote cell survival or lead to cell death <br>
-Stabilization or activation of p53 <br>