tbResList Print — CBD Cannabidiol

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Product

CBD Cannabidiol
Description: <b>Cannabidiol (CBD)</b> is a cannabinoid compound found in cannabis plants.<br>
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid derived from Cannabis sativa that has drawn interest for its potential anticancer properties. <br>
Pathways:<br>
-Mitochondrial dysfunction, with loss of membrane potential leading to the release of cytochrome c and activation of caspase cascades<br>
-Receptor-Mediated Signaling (CB Receptors and Beyond)<br>
-Can increase reactive oxygen species (ROS)<br>
-Can induce ER stress, which activates the unfolded protein response.<br>
-Suppress key survival and proliferation signaling cascades such as the PI3K/Akt/mTOR pathway.<br>
-Impair angiogenesis<br>


Pathway results for Effect on Cancer / Diseased Cells

Core Metabolism/Glycolysis ⓘ

lipoGen↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↑, 1,   EMT↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2023Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesisPatrycja BielawiecPMC9988888https://pmc.ncbi.nlm.nih.gov/articles/PMC9988888/0
2022Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathwayPanFeng Feng35960375https://pubmed.ncbi.nlm.nih.gov/35960375/0