tbResList Print — CUR Curcumin

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Product

CUR Curcumin
Description: <b>Curcumin</b> is the main active ingredient in Turmeric. Member of the ginger family.Curcumin is a polyphenol extracted from turmeric with anti-inflammatory and antioxidant properties.<br>
- Has <a href="tbResList.php?qv=65&tsv=835&wNotes=on">iron-chelating</a>, iron-chelating properties.
<a href="tbResList.php?qv=65&tsv=573&wNotes=on">Ferritin</a>.
But still known to increase
<a href="tbResList.php?qv=65&tsv=160&wNotes=on">Iron</a> in Cancer cells.
<br>
- <a href="tbResList.php?qv=65&tsv=137&wNotes=on&word=GSH↓">GSH</a>
depletion in cancer cells, exhaustion of the antioxidant defense system.
But still raises
<a href="tbResList.php?qv=65&tsv=137&wNotes=on&word=GSH↑">GSH↑</a> in normal cells.<br>
- Higher concentrations (5-10 μM) of curcumin induce autophagy and ROS production<br>
- Inhibition of
<a href="tbResList.php?qv=65&wNotes=on&word=Trx">TrxR</a>,
shifting the enzyme from an antioxidant to a prooxidant<br>
- Strong inhibitor of
<a href="tbResList.php?qv=65&tsv=125&wNotes=on">Glo-I</a>,
, causes depletion of cellular ATP and GSH<br>
- Curcumin has been found to act as an activator of
<a href="tbResList.php?qv=65&tsv=226&wNotes=on&word=NRF2↑">Nrf2</a>,
(maybe bad in cancer cells?), hence could be combined with Nrf2 knockdown<br>
-may suppress CSC: suppresses self-renewal and pathways (Wnt/Notch/Hedgehog).<br>

<br>
<p><b>Curcumin</b> — Curcumin is a turmeric-derived polyphenolic curcuminoid and diarylheptanoid from <i>Curcuma longa</i>, functionally best classified as a natural-product small molecule / nutraceutical candidate with pleiotropic redox, inflammatory, transcriptional, metabolic, and chemosensitizing activity. The standard abbreviation is <b>CUR</b>. It is the principal active pigment of turmeric rhizome, usually studied as purified curcumin, curcuminoid mixtures, turmeric extract, phytosomal curcumin, liposomal curcumin, nanoparticle curcumin, or piperine-enhanced formulations. Its oncology relevance is mechanistically broad but clinically constrained by poor aqueous solubility, rapid metabolism, low free systemic exposure, formulation variability, and insufficient well-powered cancer outcome trials.</p>

<p><b>Primary mechanisms (ranked):</b></p>
<ol>
<li>Suppression of NF-κB / STAT3 inflammatory-survival signaling, reducing cytokine, COX-2, iNOS, anti-apoptotic, invasion, and treatment-resistance programs.</li>
<li>Biphasic redox modulation: ROS buffering in normal/inflamed tissue but ROS↑, GSH depletion, thioredoxin reductase disruption, and oxidative stress amplification in susceptible cancer models at sufficient exposure.</li>
<li>Mitochondrial injury and intrinsic apoptosis, including mitochondrial membrane potential loss, cytochrome-c release, caspase activation, PARP cleavage, and ER-stress/UPR involvement.</li>
<li>PI3K/AKT/mTOR and MAPK pathway modulation, contributing to growth arrest, autophagy modulation, apoptosis sensitization, and reduced survival signaling.</li>
<li>Wnt/β-catenin, Hedgehog/GLI, Notch, and cancer-stem-cell suppression, reducing stemness, EMT, invasion, and recurrence-associated phenotypes in models.</li>
<li>Hypoxia / HIF-1α and glycolysis inhibition, including reduced GLUT1, HK2, LDHA, PKM2, lactate/ECAR, and Warburg-like metabolic support in selected models.</li>
<li>Anti-angiogenic and anti-metastatic modulation, including VEGF, MMPs, uPA, CXCR4/SDF-1, TGF-β/α-SMA, FAK, and EMT-related axes.</li>
<li>Epigenetic and transcriptional reprogramming, including reported HDAC, DNMT, EZH2, Sp-family, p53, and microRNA-related effects.</li>
<li>NRF2 modulation: generally cytoprotective in normal cells but potentially protective for cancer cells when NRF2 is activated; NRF2 suppression/knockdown can increase curcumin-induced ROS stress in some tumor models.</li>
<li>Chemosensitization and radiosensitization, with parallel normal-tissue protective signals reported in some mucositis, dermatitis, oxidative-stress, and radioprotection contexts.</li>
</ol>

<p><b>Bioavailability / PK relevance:</b> Conventional oral curcumin has poor systemic bioavailability because of low solubility, low absorption, rapid conjugation, and rapid elimination. Oral trials have used doses up to gram-level daily dosing, but circulating free curcumin is typically low; measured plasma exposure often reflects conjugated curcumin. Piperine, phospholipid/phytosome, micellar, liposomal, nanoparticle, and other enhanced formulations can raise exposure, but each formulation should be treated as a distinct translational entity. Delivery constraints are central for oncology interpretation.</p>

<p><b>In-vitro vs systemic exposure relevance:</b> Common in-vitro anticancer concentrations, often in the low-to-mid micromolar range and sometimes higher, frequently exceed achievable free plasma exposure from standard oral curcumin. Therefore, direct systemic anticancer claims from cell culture should be weighted cautiously unless supported by tissue-local exposure, enhanced formulation data, local delivery, IV/liposomal delivery, or clinically measured pharmacodynamic biomarkers.</p>

<p><b>Clinical evidence status:</b> Preclinical evidence is extensive; human oncology evidence is mainly small human, biomarker, pilot, chemoprevention, adjunctive, symptom-management, and formulation trials. Current authoritative oncology summaries judge evidence inadequate to recommend curcumin-containing products as cancer treatment or as routine adjunct anticancer therapy, although symptom-support areas such as oral mucositis, radiation dermatitis, oxidative-status measures, and quality of life have more suggestive but still confirmatory-level evidence.</p>

<br>
Clinical studies testing curcumin in cancer patients have used a range of dosages, often between 500 mg and 8 g per day; however, many studies note that doses on the lower end may not achieve sufficient plasma concentrations for a therapeutic anticancer effect in humans.<br>
• Formulations designed to improve curcumin absorption (like curcumin combined with piperine, nanoparticle formulations, or liposomal curcumin) are often employed in clinical trials to enhance its bioavailability.<br>

<br>
-Note <a href="tbResList.php?qv=65&tsv=1109&wNotes=on&exSp=open">half-life</a> 6 hrs.<br>
<a href="tbResList.php?qv=65&tsv=792&wNotes=on&exSp=open">BioAv</a> is poor, use piperine or other
<a href="https://nestronics.ca/dbx/tbResList.php?qv=65&qv2=&tsv=1310&ssv=%25&esv=2&wNotes=on&exSp=open"> enhancers</a>
<br>
Pathways:<br>

<!-- ROS : MMP↓, ER Stress↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, UPR↑, cl-PARP↑-->
- induce
<a href="tbResList.php?qv=65&tsv=275&wNotes=on">ROS</a> production at high concentration. Lowers ROS at lower concentrations<br>
curcumin can act as a pro-oxidant when blue light is applied<br>
- ROS↑ related:
<a href="tbResList.php?qv=65&tsv=197&wNotes=on&word=MMP↓">MMP↓</a>(ΔΨm),
<a href="tbResList.php?qv=65&tsv=103&wNotes=on">ER Stress↑</a>,
<a href="tbResList.php?qv=65&tsv=459&wNotes=on">UPR↑</a>,
<a href="tbResList.php?qv=65&tsv=356&wNotes=on">GRP78↑</a>,
<a href="tbResList.php?qv=65&tsv=77&wNotes=on">Cyt‑c↑</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=Casp">Caspases↑</a>,
<a href="tbResList.php?qv=65&tsv=82&wNotes=on&word=DNAdam↑">DNA damage↑</a>,
<a href="tbResList.php?qv=65&tsv=239&wNotes=on">cl-PARP↑</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=HSP">HSP↓</a>
<br>

<!-- ANTIOXIDANT : NRF2, SOD, GSH, CAT, HO-1, GPx, GPX4, -->
- Lowers AntiOxidant defense in Cancer Cells:
<a href="tbResList.php?qv=65&tsv=137&wNotes=on&word=GSH↓">GSH↓</a>
<a href="tbResList.php?qv=65&tsv=46&wNotes=on">Catalase↓</a>
<a href="tbResList.php?qv=65&tsv=597&wNotes=on">HO1↓</a>
<a href="tbResList.php?qv=65&wNotes=on&word=GPx">GPx↓</a>
<br>
but conversely is known as a
<a href="tbResList.php?qv=65&tsv=226&wNotes=on&word=NRF2↑">NRF2↑</a> activator in cancer
<br>
- Raises
<a href="tbResList.php?qv=65&tsv=1103&wNotes=on&word=antiOx↑">AntiOxidant</a>
defense in Normal Cells:
<a href="tbResList.php?qv=65&tsv=275&wNotes=on&word=ROS↓">ROS↓</a>,
<a href="tbResList.php?qv=65&tsv=226&wNotes=on&word=NRF2↑">NRF2↑</a>,
<a href="tbResList.php?qv=65&tsv=298&wNotes=on&word=SOD↑">SOD↑</a>,
<a href="tbResList.php?qv=65&tsv=137&wNotes=on&word=GSH↑">GSH↑</a>,
<a href="tbResList.php?qv=65&tsv=46&wNotes=on&word=Catalase↑">Catalase↑</a>,
<br>

<!-- INFLAMMATION : NF-kB↓, COX2↓, COX2↓ PRO-INFL CYTOKINES: IL-1β↓, TNF-α↓, IL-6↓, IL-8↓, -->
- lowers
<a href="tbResList.php?qv=65&tsv=953&wNotes=on&word=Inflam">Inflammation</a> :
<a href="tbResList.php?qv=65&tsv=214&wNotes=on&word=NF-kB↓">NF-kB↓</a>,
<a href="tbResList.php?qv=65&tsv=66&wNotes=on&word=COX2↓">COX2↓</a>,
<a href="tbResList.php?qv=65&tsv=235&wNotes=on&word=p38↓">p38↓</a>, Pro-Inflammatory Cytokines :
<a href="tbResList.php?qv=65&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>,
<a href="tbResList.php?qv=65&tsv=158&wNotes=on&word=IL6↓">IL-6↓</a>,
<a href="tbResList.php?qv=65&tsv=368&wNotes=on&word=IL8↓">IL-8↓</a>
<br>



<!-- GROWTH/METASTASES : EMT↓, MMPs↓, MMP2↓, MMP9↓, IGF-1, uPA↓, VEGF↓, ERK↓
inhibiting metastasis-associated proteins such as ROCK1, FAK, (RhoA), NF-κB and u-PA, MMP-1 and MMP-13.-->
- inhibit Growth/Metastases :
<a href="tbResList.php?qv=65&tsv=604&wNotes=on">TumMeta↓</a>,
<a href="tbResList.php?qv=65&tsv=323&wNotes=on">TumCG↓</a>,
<a href="tbResList.php?qv=65&tsv=96&wNotes=on">EMT↓</a>,
<a href="tbResList.php?qv=65&tsv=204&wNotes=on">MMPs↓</a>,
<a href="tbResList.php?qv=65&tsv=201&wNotes=on">MMP2↓</a>,
<a href="tbResList.php?qv=65&tsv=203&wNotes=on">MMP9↓</a>,
<a href="tbResList.php?qv=65&tsv=428&wNotes=on">uPA↓</a>,
<a href="tbResList.php?qv=65&tsv=334&wNotes=on">VEGF↓</a>,
<a href="tbResList.php?qv=65&tsv=214&wNotes=on">NF-κB↓</a>,
<a href="tbResList.php?qv=65&tsv=79&wNotes=on">CXCR4↓</a>,
<a href="tbResList.php?qv=65&tsv=1247&wNotes=on">SDF1↓</a>,
<a href="tbResList.php?qv=65&tsv=304&wNotes=on">TGF-β↓</a>,
<a href="tbResList.php?qv=65&tsv=719&wNotes=on">α-SMA↓</a>,
<a href="tbResList.php?qv=65&tsv=105&wNotes=on">ERK↓</a>
<br>

<!-- REACTIVATE GENES : HDAC↓, DNMT1↓, DNMT3A↓, EZH2↓, P53↑, -->
- reactivate genes thereby inhibiting cancer cell growth :
<a href="tbResList.php?qv=65&tsv=140&wNotes=on">HDAC↓</a>,
<a href="tbResList.php?qv=65&tsv=85&wNotes=on">DNMT1↓</a>,
<a href="tbResList.php?qv=65&tsv=86&wNotes=on">DNMT3A↓</a>,
<a href="tbResList.php?qv=65&tsv=108&wNotes=on">EZH2↓</a>,
<a href="tbResList.php?qv=65&tsv=236&wNotes=on">P53↑</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=HSP">HSP↓</a>,
<a href="tbResList.php?qv=65&tsv=506&wNotes=on">Sp proteins↓</a>,
<br>

<!-- CELL CYCLE ARREST : TumCCA↑, cyclin D1↓, cyclin E↓, CDK2↓, CDK4↓, CDK6↓ -->
- cause Cell cycle arrest :
<a href="tbResList.php?qv=65&tsv=322&wNotes=on">TumCCA↑</a>,
<a href="tbResList.php?qv=65&tsv=73&wNotes=on">cyclin D1↓</a>,
<a href="tbResList.php?qv=65&tsv=467&wNotes=on">CDK2↓</a>,
<a href="tbResList.php?qv=65&tsv=894&wNotes=on">CDK4↓</a>,
<a href="tbResList.php?qv=65&tsv=895&wNotes=on">CDK6↓</a>,
<br>

<!-- MIGRATION/INVASION : TumCMig↓, TumCI↓, FAK↓, ERK↓, -->
- inhibits Migration/Invasion :
<a href="tbResList.php?qv=65&tsv=326&wNotes=on">TumCMig↓</a>,
<a href="tbResList.php?qv=65&tsv=324&wNotes=on">TumCI↓</a>,
<a href="tbResList.php?qv=65&tsv=105&wNotes=on">ERK↓</a>,
<a href="tbResList.php?qv=65&tsv=96&wNotes=on">EMT↓</a>,
<a href="tbResList.php?qv=65&tsv=1117&wNotes=on">TOP1↓</a>,
<a href="tbResList.php?qv=65&tsv=657&wNotes=on">TET1↓</a>,
<br>

<!-- GLYCOLYSIS : ATP↓, HIF-1α↓, PKM2↓, cMyc↓, PDK1↓, GLUT1↓, LDHA↓, HK2↓, Glucose↓, GlucoseCon↓, lactateProd, OXPHOS -->
- inhibits
<a href="tbResList.php?qv=65&tsv=129&wNotes=on">glycolysis</a>
/<a href="tbResList.php?qv=65&tsv=947&wNotes=on">Warburg Effect</a> and
<a href="tbResList.php?qv=65&tsv=21&wNotes=on&word=ATP↓">ATP depletion</a> :
<a href="tbResList.php?qv=65&tsv=143&wNotes=on">HIF-1α↓</a>,
<a href="tbResList.php?qv=65&tsv=772&wNotes=on">PKM2↓</a>,
<a href="tbResList.php?qv=65&tsv=35&wNotes=on">cMyc↓</a>,
<a href="tbResList.php?qv=65&tsv=566&wNotes=on&word=GLUT">GLUT1↓</a>,
<a href="tbResList.php?qv=65&tsv=175&wNotes=on&word=LDH">LDHA↓</a>,
<a href="tbResList.php?qv=65&tsv=773&wNotes=on">HK2↓</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=PFK">PFKs↓</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=PDK">PDKs↓</a>,
<a href="tbResList.php?qv=65&tsv=773&wNotes=on">HK2↓</a>,
<a href="tbResList.php?qv=65&tsv=847&wNotes=on">ECAR↓</a>,
<a href="tbResList.php?qv=65&tsv=230&wNotes=on">OXPHOS↓</a>,
<a href="tbResList.php?qv=65&tsv=356&wNotes=on">GRP78↑</a>,
<a href="tbResList.php?qv=65&tsv=623&wNotes=on">GlucoseCon↓</a>
<br>


<!-- ANGIOGENESIS : VEGF↓, VEGFR2↓, HIF-1α↓, NOTCH↓, FGF↓, PDGF↓, EGFR↓ ITG(Integrins↓)-->
- inhibits
<a href="tbResList.php?qv=65&tsv=447&wNotes=on">angiogenesis↓</a> :
<a href="tbResList.php?qv=65&tsv=334&wNotes=on">VEGF↓</a>,
<a href="tbResList.php?qv=65&tsv=143&wNotes=on">HIF-1α↓</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=NOTCH">Notch↓</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=FGF">FGF↓</a>,
<a href="tbResList.php?qv=65&tsv=361&wNotes=on">PDGF↓</a>,
<a href="tbResList.php?qv=65&tsv=94&wNotes=on&word=EGFR↓">EGFR↓</a>,
<a href="tbResList.php?qv=65&&wNotes=on&word=ITG">Integrins↓</a>,
<br>

<!-- CSCs : CSC↓, CK2↓, Hh↓, GLi↓, GLi1↓, -->
- inhibits Cancer Stem Cells :
<a href="tbResList.php?qv=65&tsv=795&wNotes=on">CSC↓</a>,
<a href="tbResList.php?qv=65&tsv=524&wNotes=on">CK2↓</a>,
<a href="tbResList.php?qv=65&tsv=141&wNotes=on">Hh↓</a>,
<a href="tbResList.php?qv=65&tsv=124&wNotes=on">GLi1↓</a>,
<a href="tbResList.php?qv=65&tsv=677&wNotes=on">CD133↓</a>,
<a href="tbResList.php?qv=65&tsv=655&wNotes=on">CD24↓</a>,
<a href="tbResList.php?qv=65&tsv=342&wNotes=on">β-catenin↓</a>,
<a href="tbResList.php?qv=65&tsv=357&wNotes=on">n-myc↓</a>,
<a href="tbResList.php?qv=65&tsv=656&wNotes=on">sox2↓</a>,
<a href="tbResList.php?qv=65&tsv=508&wNotes=on">OCT4↓</a>,
<br>

<!-- OTHERS : -->
- Others: <a href="tbResList.php?qv=65&tsv=252&wNotes=on">PI3K↓</a>,
<a href="tbResList.php?qv=65&tsv=4&wNotes=on">AKT↓</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=JAK">JAK↓</a>,
<a href="tbResList.php?qv=65&wNotes=on&word=STAT">STAT↓</a>,
<a href="tbResList.php?qv=65&tsv=377&wNotes=on">Wnt↓</a>,
<a href="tbResList.php?qv=65&tsv=342&wNotes=on">β-catenin↓</a>,
<a href="tbResList.php?qv=65&tsv=9&wNotes=on">AMPK↓</a>,
<a href="tbResList.php?qv=65&tsv=105&wNotes=on">ERK↓</a>,
<a href="tbResList.php?qv=65&tsv=168&wNotes=on">JNK</a>,
<a href="tbResList.php?qv=65&tsv=825&wNotes=on">TrxR**</a>,
<br>


<!-- SYNERGIES : -->
- Synergies:
<a href="tbResList.php?qv=65&tsv=1106&wNotes=on">chemo-sensitization</a>,
<a href="tbResList.php?qv=65&tsv=1171&wNotes=on">chemoProtective</a>,
<a href="tbResList.php?qv=65&tsv=1107&wNotes=on">RadioSensitizer</a>,
<a href="tbResList.php?qv=65&tsv=1185&wNotes=on">RadioProtective</a>,
<a href="tbResList.php?qv=65&tsv=961&esv=2&wNotes=on&exSp=open">Others(review target notes)</a>,
<a href="tbResList.php?qv=65&tsv=1105&wNotes=on">Neuroprotective</a>,
<a href="tbResList.php?qv=65&tsv=557&wNotes=on">Cognitive</a>,
<a href="tbResList.php?qv=65&tsv=1175&wNotes=on">Renoprotection</a>,
<a href="tbResList.php?qv=65&tsv=1179&wNotes=on">Hepatoprotective</a>,
<a href="tbResList.php?&qv=65&tsv=1188&wNotes=on">CardioProtective</a>,

<br>
<br>
<!-- SELECTIVE: -->
- Selectivity:
<a href="tbResList.php?qv=65&tsv=1110&wNotes=on">Cancer Cells vs Normal Cells</a><br>
<br>





<h3>Curcumin Cancer Mechanism Ranking</h3>
<table border="1" cellpadding="4" cellspacing="0">
<tr>
<th>Rank</th>
<th>Pathway / Axis</th>
<th>Cancer Cells</th>
<th>Normal Cells</th>
<th>TSF</th>
<th>Primary Effect</th>
<th>Notes / Interpretation</th>
</tr>

<tr>
<td>1</td>
<td>NF-κB / STAT3 inflammatory survival signaling</td>
<td>NF-κB ↓; STAT3 ↓; IL-6/TNF-α/COX-2/iNOS ↓; Bcl-2/Bcl-xL/survivin programs ↓</td>
<td>Inflammatory tone ↓; tissue-protective anti-inflammatory effect likely context-dependent</td>
<td>R/G</td>
<td>Reduced survival, inflammation, invasion, and therapy-resistance signaling</td>
<td>Most central and industry-relevant axis; explains many downstream effects but is not curcumin-specific.</td>
</tr>

<tr>
<td>2</td>
<td>Biphasic redox stress and antioxidant buffering</td>
<td>ROS ↑ (dose-dependent); GSH ↓; antioxidant reserve ↓; oxidative apoptosis ↑</td>
<td>ROS ↓; NRF2/SOD/GSH/catalase/HO-1 often ↑ in stress models</td>
<td>R/G</td>
<td>Selective redox pressure in susceptible tumor cells with normal-cell protection in lower-stress settings</td>
<td>Direction depends strongly on concentration, formulation, light exposure, basal redox state, and tumor antioxidant capacity.</td>
</tr>

<tr>
<td>3</td>
<td>Thioredoxin reductase and GSH linked redox systems</td>
<td>TrxR inhibition or redox cycling ↑; GSH depletion ↑; oxidative stress ↑</td>
<td>Usually buffered or antioxidant response ↑ at non-toxic exposure</td>
<td>R/G</td>
<td>Collapse of tumor redox compensation</td>
<td>Mechanistically important for ROS amplification and radiosensitization; achievable exposure remains a major constraint.</td>
</tr>

<tr>
<td>4</td>
<td>Mitochondrial depolarization and intrinsic apoptosis</td>
<td>ΔΨm ↓; cytochrome-c ↑; caspase-3/9 ↑; PARP cleavage ↑; apoptosis ↑</td>
<td>Generally ↔ or protected under oxidative/inflammatory stress</td>
<td>R/G</td>
<td>Execution of apoptosis after upstream redox and survival-signal disruption</td>
<td>Central cytotoxic endpoint in many cell models; often downstream of ROS, ER stress, AKT/mTOR suppression, or p53 modulation.</td>
</tr>

<tr>
<td>5</td>
<td>PI3K / AKT / mTOR and autophagy balance</td>
<td>PI3K ↓; AKT ↓; mTOR ↓; survival signaling ↓; autophagy ↑ or mixed</td>
<td>Stress-adaptive autophagy ↔ or ↑ (context-dependent)</td>
<td>R/G</td>
<td>Growth suppression and apoptosis sensitization</td>
<td>Autophagy may be cytotoxic or protective depending on model and timing; combination logic may require autophagy-state interpretation.</td>
</tr>

<tr>
<td>6</td>
<td>Wnt / β-catenin / Hedgehog / Notch stemness signaling</td>
<td>β-catenin ↓; GLI/Hedgehog ↓; Notch ↓; CD133/CD44/OCT4/SOX2-like stemness markers ↓</td>
<td>Generally ↔; possible normal stem-cell effects are tissue/context-dependent</td>
<td>G</td>
<td>Reduced cancer stemness, EMT, self-renewal, and recurrence-associated phenotypes</td>
<td>Important for anti-metastatic and anti-CSC positioning; evidence is mainly preclinical.</td>
</tr>

<tr>
<td>7</td>
<td>HIF-1α / glycolysis / Warburg metabolism</td>
<td>HIF-1α ↓; GLUT1 ↓; HK2 ↓; LDHA ↓; PKM2 ↓; lactate/ECAR ↓; ATP stress ↑</td>
<td>Metabolic effects ↔ or adaptive; normal-cell toxicity depends on exposure</td>
<td>G</td>
<td>Reduced hypoxic adaptation and glycolytic energy support</td>
<td>Mechanistically relevant but formulation and tissue exposure are critical; hypoxic tumors may be more relevant than normoxic cell culture.</td>
</tr>

<tr>
<td>8</td>
<td>EMT / invasion / metastasis matrix axis</td>
<td>EMT ↓; MMP2/MMP9 ↓; uPA ↓; FAK ↓; CXCR4/SDF-1 ↓; migration/invasion ↓</td>
<td>Inflammation-linked remodeling ↓; wound-healing effects context-dependent</td>
<td>G</td>
<td>Anti-invasive and anti-metastatic phenotype</td>
<td>Strongly supported in models; clinical anti-metastatic efficacy is not established.</td>
</tr>

<tr>
<td>9</td>
<td>VEGF / angiogenesis / hypoxia interface</td>
<td>VEGF ↓; HIF-1α ↓; angiogenic signaling ↓</td>
<td>Angiogenesis modulation ↔ or ↓ (context-dependent)</td>
<td>G</td>
<td>Reduced tumor vascular-support signaling</td>
<td>Overlaps with NF-κB, HIF-1α, STAT3, and inflammatory cytokine suppression.</td>
</tr>

<tr>
<td>10</td>
<td>Epigenetic and transcriptional reprogramming</td>
<td>HDAC ↓; DNMT1/3A ↓; EZH2 ↓; Sp proteins ↓; p53 ↑ or restored in selected models</td>
<td>Broad transcriptional effects possible; selectivity uncertain</td>
<td>G</td>
<td>Reactivation of growth-control and differentiation-associated programs</td>
<td>Biologically plausible but highly model-dependent; direct target specificity is lower than pathway-level interpretation.</td>
</tr>

<tr>
<td>11</td>
<td>Ferroptosis and iron redox stress</td>
<td>Iron/redox stress ↑; lipid peroxidation ↑; GPX4/GSH axis may ↓ (model-dependent)</td>
<td>Iron-chelation and antioxidant protection may occur (context-dependent)</td>
<td>R/G</td>
<td>Potential ferroptosis contribution in susceptible tumor models</td>
<td>Curcumin can behave as an iron chelator, antioxidant, or pro-oxidant depending on exposure, formulation, and cancer redox context.</td>
</tr>

<tr>
<td>12</td>
<td>NRF2 cytoprotection risk</td>
<td>NRF2 ↑ may protect tumor cells; NRF2 depletion can enhance curcumin-induced ROS stress in some models</td>
<td>NRF2 ↑ supports antioxidant and anti-inflammatory tissue protection</td>
<td>G</td>
<td>Dual-edged stress-response modulation</td>
<td>Important caution for antioxidant matrix use: NRF2 activation is favorable in normal-cell protection but may be undesirable in NRF2-addicted tumors.</td>
</tr>

<tr>
<td>13</td>
<td>Chemosensitization and radiosensitization</td>
<td>Chemo response ↑; radiation response ↑; apoptosis ↑; resistance pathways ↓</td>
<td>Chemo/radiation injury may ↓ in mucositis, dermatitis, and oxidative-stress contexts</td>
<td>R/G</td>
<td>Adjunct sensitization with possible normal-tissue protection</td>
<td>Attractive translational axis, but clinical evidence remains mainly pilot/small-study; interaction risk should be checked per regimen.</td>
</tr>

<tr>
<td>14</td>
<td>Clinical Translation Constraint</td>
<td>Free systemic exposure often insufficient for direct cytotoxic extrapolation from in-vitro micromolar data</td>
<td>Enhanced formulations may improve exposure but may also alter safety, liver-risk profile, and interaction potential</td>
<td>G</td>
<td>Bioavailability and formulation dominate translational interpretation</td>
<td>Separate ordinary curcumin, turmeric extract, piperine-enhanced, phytosomal, micellar, liposomal, nanoparticle, and IV/liposomal products where possible.</td>
</tr>
</table>

<p><b>TSF legend:</b></p>
<p>P: 0–30 min</p>
<p>R: 30 min–3 hr</p>
<p>G: &gt;3 hr</p>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress

antiOx↓, 1,   ARE/EpRE↑, 1,   ATF3↑, 1,   Catalase↓, 1,   Fenton↑, 4,   Ferroptosis↑, 7,   GPx↓, 2,   GPx1↓, 1,   GPx4↓, 1,   GSH↑, 1,   GSH↓, 3,   mt-GSH↓, 1,   GSH/GSSG↓, 2,   GSTP1/GSTπ↓, 1,   GSTs↑, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↑, 5,   HO-1↓, 1,   Iron↑, 6,   IRP1↑, 1,   Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MDA↑, 5,   NADH↓, 1,   NFE2L2↑, 1,   NQO1↑, 1,   NRF2↑, 6,   NRF2↝, 1,   NRF2↓, 1,   OXPHOS↑, 1,   OXPHOS↓, 1,   PAO↑, 1,   ROS↝, 1,   ROS↑, 11,   ROS⇅, 1,   ROS↓, 1,   SOD↑, 1,   SOD1↓, 1,   Trx↓, 1,   Trx1↓, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 10,   TrxR1↓, 2,   xCT↓, 1,  

Metal & Cofactor Biology

Ferritin↓, 1,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics

AIF↑, 2,   ATP↓, 2,   CDC25↓, 2,   EGF↑, 1,   ETC↓, 1,   MEK↑, 1,   MEK↓, 1,   MKP5↑, 1,   MMP↓, 4,   MPT↑, 2,   mtDam↑, 2,   p‑p42↓, 1,   Raf↓, 2,   SDH↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis

p‑ACC-α↑, 1,   ACOX1↑, 1,   ACSL4↑, 1,   ALAT↑, 1,   ALDOA↓, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   cMyc↓, 3,   CPT1A↑, 1,   DGAT1↓, 1,   ECAR↓, 1,   Elvol3↓, 1,   ENO2↓, 1,   ERCC1↓, 1,   FASN↓, 3,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 4,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   glut↓, 1,   GlutMet↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   IR↓, 1,   lactateProd↓, 2,   lactateProd↑, 1,   LAR↓, 1,   LDHA↓, 3,   LDHB↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NNMT↓, 1,   PDK1↓, 2,   p‑PDK1↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PGAM1↓, 1,   PGC1A↑, 1,   PGK1↓, 1,   PGM1↓, 1,   PI3K/Akt↓, 2,   PI3k/Akt/mTOR↓, 1,   PI3K/mTOR/ETS2↓, 1,   p‑PIK3R1↓, 1,   PKM2↓, 7,   PPARα↝, 1,   PPARγ↑, 3,   PSMB5↓, 1,   Pyruv↓, 1,   p‑S6↓, 1,   p‑S6K↓, 1,   S6K↓, 1,   SCD1↓, 2,   SREBF2↓, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↑, 2,   Warburg↓, 3,  

Cell Death

14-3-3 proteins↓, 1,   Akt↓, 1,   Akt↝, 1,   Akt↑, 1,   p‑Akt↓, 6,   Apoptosis↑, 24,   Apoptosis↝, 1,   Apoptosis↓, 1,   BAD↝, 1,   BAD↑, 1,   p‑BAD↓, 1,   Bak↑, 2,   BAX↝, 2,   BAX↑, 9,   Bax:Bcl2↑, 3,   Bcl-2↓, 15,   Bcl-2↝, 1,   Bcl-xL↝, 1,   Bcl-xL↓, 5,   BID↑, 2,   BIM↑, 1,   Casp↑, 4,   Casp12↑, 1,   Casp3↑, 3,   Casp3↝, 1,   Casp3↓, 1,   cl‑Casp3↑, 2,   proCasp3↓, 1,   Casp8↑, 4,   Casp9↑, 2,   Casp9↓, 1,   cl‑Casp9↑, 1,   proCasp9↑, 1,   CBP↓, 1,   CK2↓, 1,   Cyt‑c↝, 1,   Cyt‑c↑, 9,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 7,   Hippo↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 2,   JNK↑, 3,   JNK↝, 1,   JNK↓, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 4,   Mcl-1↑, 1,   MCT1↓, 2,   MDM2↓, 2,   MEG3↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-7641↓, 1,   Myc↓, 1,   NOXA↑, 1,   p27↑, 1,   p38↓, 3,   p‑p38↑, 1,   Paraptosis↑, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 3,   TumCD↓, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction

FOXD3↑, 1,   H3K18↓, 1,   HER2/EBBR2↓, 3,   miR-25-5p↓, 1,   p‑p70S6↓, 1,   PAK↓, 1,   RTK-RAS↓, 1,   SOX9?, 1,   Sp1/3/4↓, 6,  

Transcription & Epigenetics

cJun↓, 2,   COMP↓, 1,   EZH2↓, 2,   H19↓, 1,   H3K4↓, 1,   HATs↓, 2,   KCNQ1OT1↓, 1,   Matr↓, 1,   MeCP2↓, 1,   miR-143↑, 1,   miR-145↑, 1,   miR-192-5p↑, 1,   miR-205↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 5,   miR-30a-5p↑, 1,   miR-409-3p↑, 1,   other↝, 7,   other↓, 1,   other↑, 1,   PhotoS↑, 2,   p‑pRB↓, 1,   sonoS↑, 2,   tumCV↓, 2,   USF1↑, 1,  

Protein Folding & ER Stress

ATF6↑, 1,   ATFs↑, 1,   CHOP↑, 2,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 2,   GRP78/BiP↓, 1,   HSF1↓, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↓, 1,   e-HSP70/HSPA5↓, 1,   HSP90↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes

ATG3↑, 1,   ATG5↑, 1,   autolysosome↑, 1,   Beclin-1↑, 3,   Beclin-1↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3I↓, 1,   LC3II↑, 1,   LC3II↓, 1,   LC3s↑, 1,   p62↓, 3,   p62↑, 3,   TumAuto↑, 4,   TumAuto↓, 1,  

DNA Damage & Repair

ATR↑, 1,   BRCA1↑, 1,   DFF45↓, 1,   DNA-PK↑, 1,   DNAdam↑, 3,   mt-DNAdam↑, 1,   DNMT1↓, 4,   DNMT3A↑, 1,   DNMT3A↓, 1,   DNMTs↓, 5,   GADD45A↑, 1,   NBR2↑, 1,   p16↑, 1,   P53↑, 1,   P53↝, 1,   P53↓, 1,   P53?, 1,   p‑P53↑, 2,   p73↑, 1,   PARP↑, 1,   PARP↓, 1,   cl‑PARP↑, 2,   p‑PARP↑, 1,   cl‑PARP1↑, 1,   PARP1↓, 1,   PCLAF↓, 1,   PCNA↓, 1,   RAD51↑, 1,   SAPK↑, 1,   SMG1↑, 1,   TP53↑, 1,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 2,   Cyc↝, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycD1/CCND1↝, 1,   cycE1↓, 1,   cycF↓, 1,   P21↑, 3,   P21↝, 1,   TAp63α↑, 2,   TFAP2A↓, 1,   TumCCA↑, 10,   TumCCA↓, 2,  

Proliferation, Differentiation & Cell State

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 1,   AXIN1↓, 1,   Axin2↑, 1,   CD133↓, 1,   CD133↑, 1,   CD24↓, 2,   CD44↑, 1,   CD44↓, 5,   cDC2↓, 1,   CDX2↓, 1,   cFos↓, 1,   p‑cMET↓, 1,   CSCs↓, 19,   CSCsMark↓, 1,   EIF4E↓, 1,   EMT↓, 6,   EP300↓, 1,   EpCAM↓, 1,   p‑ERK↓, 1,   p‑ERK↑, 2,   ERK↓, 4,   ERK↑, 1,   FGF↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   Gli1↓, 1,   Gli1↝, 1,   GSK‐3β↓, 5,   GSK‐3β↝, 1,   GSK‐3β↑, 1,   HDAC↓, 5,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   HH↓, 8,   HH↝, 1,   Id1↓, 1,   IGF-1↓, 1,   IGFR↓, 1,   p‑Jun↑, 1,   LGR5↓, 2,   miR-101↑, 1,   miR-142-3p↑, 1,   miR-330-5p↑, 1,   miR-34a↑, 1,   miR-429↑, 1,   miR-99↑, 1,   mTOR↝, 1,   mTOR↓, 1,   p‑mTOR↓, 4,   n-MYC↓, 1,   Nanog↓, 1,   Neurog1↑, 1,   NKD2↑, 1,   NOTCH↓, 4,   NOTCH↝, 1,   NOTCH1↓, 1,   NOTCH1↝, 1,   OCT4↓, 2,   p300↓, 2,   p‑P70S6K↓, 1,   PI3K↝, 1,   PI3K↓, 10,   p‑PI3K↓, 1,   PIAS-3↑, 1,   Pirin↓, 1,   circ‑PLEKHM3↑, 1,   PRKCG↑, 1,   PTCH1↓, 1,   PTEN↝, 1,   PTEN↑, 2,   RAS↓, 2,   RPS6KA1↓, 1,   SFRP5↑, 1,   Shh↓, 1,   Smo↓, 2,   SOX2↓, 2,   Src↓, 2,   STAT↓, 3,   STAT1↓, 1,   p‑STAT1↓, 2,   p‑STAT2↓, 1,   STAT3↓, 2,   p‑STAT3↓, 4,   STAT4↓, 1,   STAT5↓, 1,   TAZ↓, 1,   p‑TAZ↑, 1,   TCF↓, 2,   TOP1↑, 1,   TOP1↓, 1,   TOP2↑, 2,   TOP2↓, 1,   TumCG↓, 4,   Wnt↓, 2,   Wnt↝, 1,   Wnt/(β-catenin)↓, 1,  

Migration

5LO↓, 2,   AGRN↓, 1,   AKR1C2↓, 1,   AP-1↝, 2,   AP-1↓, 4,   ATPase↓, 1,   BACH1↑, 1,   Ca+2↑, 2,   CAFs/TAFs↓, 1,   CD31↓, 1,   CDK4/6↓, 1,   circ-PRKCA↓, 1,   COL2A1↓, 1,   COL9A3↓, 1,   CXCL12↓, 1,   DLC1↑, 2,   E-cadherin↑, 6,   E-cadherin↓, 3,   EFEMP↓, 1,   FAK↓, 3,   FAK↝, 1,   fascin↓, 1,   Fibronectin↓, 1,   Galectin-9↓, 1,   GLI2↝, 1,   GP1BB↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,   LAMs↓, 1,   MET↑, 1,   miR-130a↓, 2,   miR-141↑, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-20↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-206↑, 2,   miR-221↓, 1,   miR-29b↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-320a↓, 1,   miR-340↑, 1,   miR-384↑, 1,   miR-491↑, 1,   miR‐222↓, 1,   MMP2↝, 1,   MMP2↓, 6,   MMP9↓, 11,   pro‑MMP9↓, 1,   MMPs↓, 6,   MRGPRF↓, 1,   MUC1↓, 1,   N-cadherin↓, 2,   NEDD9↓, 2,   p‑p44↓, 1,   PDGF↓, 1,   p‑PDGF↓, 1,   PIR↓, 1,   PKCδ↓, 1,   PTP1B↓, 1,   Rho↓, 1,   Slug↓, 2,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 1,   SPARC↓, 1,   TET1↑, 2,   TGF-β↓, 1,   TregCell↓, 1,   TRIB3↑, 1,   Trop2↓, 1,   TumCI↓, 5,   TumCMig↓, 10,   TumCP↓, 17,   TumMeta↓, 1,   TumMeta↑, 1,   Twist↓, 1,   TXNIP↑, 1,   uPA↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature

angioG↓, 1,   angioS↑, 1,   ATF4↑, 1,   ECM/TCF↓, 2,   EGFR↓, 10,   EGFR↝, 1,   EPR↑, 2,   HIF-1↓, 2,   Hif1a↓, 6,   Hif1a↝, 1,   LOX1↓, 1,   miR-126↑, 1,   miR-15↑, 1,   miR-17↓, 1,   NO↑, 1,   NO↓, 1,   PDI↑, 1,   REL↑, 1,   VEGF↝, 1,   VEGF↓, 2,   ZBTB10↑, 1,  

Barriers & Transport

GLUT1↓, 2,   MRP↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling

CD25+↓, 1,   CD4+↓, 1,   COX1↓, 2,   COX2↓, 1,   COX2↝, 1,   CRP↓, 1,   CXCc↓, 2,   CXCR4↓, 1,   DCells↑, 1,   FoxP3+↓, 1,   GM-CSF↓, 2,   HCAR1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 2,   IL18↓, 1,   IL2↓, 3,   IL5↓, 1,   IL6↓, 1,   IL6↝, 1,   IL8↓, 4,   Imm↑, 4,   Inflam↓, 3,   IκB↓, 1,   JAK↓, 1,   p‑JAK↓, 1,   p‑JAK2↓, 1,   JAK2↓, 3,   p‑JAK3↓, 1,   Macrophages↓, 1,   MCP1↓, 1,   MDSCs↓, 2,   MyD88↓, 1,   Neut↓, 1,   NF-kB↓, 1,   NF-kB↝, 1,   NK cell↑, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 2,   PD-L2↓, 1,   PGE2↓, 1,   PSA↝, 1,   PSA↓, 6,   SOCS-3↑, 1,   SOCS1↑, 1,   T-Cell↑, 4,   TILs↑, 1,   TLR4↓, 3,   TNF-α↝, 1,   TNF-α↓, 2,   TRIF↓, 1,  

Cellular Microenvironment

pH↑, 1,   TIM-3↓, 1,  

Synaptic & Neurotransmission

ADAM10↓, 1,   cholinesterase↓, 1,   MAOA↓, 1,  

Protein Aggregation

SNCG↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors

AR↝, 1,   AR↓, 12,   AR↑, 1,   CDK6↓, 1,   CYP11A1↓, 1,   CYP19↓, 1,   DHT↓, 1,   ER(estro)↓, 1,   ERβ/ESR2↑, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance

BioAv↑, 17,   BioAv↓, 15,   BioAv↝, 1,   ChemoSen↑, 29,   ChemoSen↓, 1,   CT-I↓, 1,   CYP17A1↓, 1,   Dose↝, 9,   Dose↑, 5,   Dose∅, 5,   Dose?, 1,   eff↑, 33,   eff↓, 14,   eff↝, 1,   Half-Life∅, 1,   Half-Life↝, 1,   Half-Life↓, 3,   MDR1↓, 1,   RadioS↑, 17,   RadioS∅, 1,   selectivity↑, 5,  

Clinical Biomarkers

ALAT↑, 1,   Albumin↑, 1,   ALP↑, 1,   AR↝, 1,   AR↓, 12,   AR↑, 1,   AST↑, 1,   BMPs↑, 1,   BRCA1↑, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 10,   EGFR↝, 1,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 1,   GutMicro↝, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 1,   IL6↓, 1,   IL6↝, 1,   Myc↓, 1,   PD-L1↓, 2,   PSA↝, 1,   PSA↓, 6,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes

AntiCan↑, 5,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 3,   chemoP↑, 6,   chemoPv↑, 7,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 2,   OS↓, 1,   QoL↑, 1,   radioP↑, 3,   Remission↑, 1,   toxicity↓, 6,   TumVol↑, 1,   TumVol↓, 5,   TumW↓, 1,  

Infection & Microbiome

Bacteria↑, 1,   CD8+↑, 1,   IRF3↓, 1,  
Total Targets: 675

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress

antiOx↑, 29,   antiOx↓, 1,   Catalase↑, 11,   Ferroptosis↓, 1,   GPx↑, 3,   GSH↑, 13,   GSR↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 12,   HO-2↓, 1,   Keap1↓, 1,   lipid-P↓, 10,   MDA↓, 10,   MDA↑, 3,   MPO↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↑, 19,   NRF2↓, 1,   RNS↓, 1,   ROS↓, 39,   SIRT3↑, 1,   SOD↑, 13,   SOD↓, 1,   mt-SOD↑, 1,   TAC↑, 2,   Trx↑, 1,  

Metal & Cofactor Biology

Ferritin↑, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics

AIF↓, 1,   ATP↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis

12LOX↑, 1,   Acetyl-CoA↓, 1,   ALAT↓, 2,   AMPK↑, 3,   CREB↑, 2,   CRM↓, 1,   cytoP450↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDH↓, 1,   LDL↓, 3,   NADPH↑, 1,   NADPH↓, 1,   PPARγ↑, 1,   SIRT1↑, 4,  

Cell Death

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 2,   Apoptosis↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↓, 1,   CK2↑, 1,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 5,  

Kinase & Signal Transduction

Sp1/3/4↓, 2,  

Transcription & Epigenetics

Ach↑, 3,   HATs↓, 1,   other↓, 7,  

DNA Damage & Repair

DNAdam↓, 1,   P53↓, 2,  

Proliferation, Differentiation & Cell State

ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 6,   HDAC↑, 1,   mTOR↓, 1,   mTORC1↓, 1,   neuroG↑, 1,   p300↓, 1,   PI3K↑, 1,   STAT↓, 1,   STAT3↓, 1,  

Migration

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 2,   APP↓, 1,   mt-ATPase↑, 1,   Ca+2↓, 1,   CDK5↓, 3,   COL3A1↓, 1,   miR-22↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↑, 1,   MMPs↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TXNIP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature

NO↓, 4,   NO↑, 2,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport

BBB↑, 8,   BBB↓, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MRP↓, 1,  

Immune & Inflammatory Signaling

COX2↓, 9,   COX2↑, 1,   COX2?, 1,   CRP↓, 1,   ICAM-1↓, 1,   IL1↓, 3,   IL10↑, 1,   IL12↓, 3,   IL17↓, 1,   IL1β↓, 8,   IL2↑, 1,   IL2↓, 2,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 8,   IL8↓, 2,   INF-γ↓, 2,   Inflam↓, 35,   Inflam↑, 1,   MCP1↓, 3,   NF-kB↓, 18,   PGE2↓, 4,   TLR2↓, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission

AChE↓, 18,   ADAM10↑, 2,   ADAM10↝, 1,   BChE↓, 2,   BDNF↑, 6,   ChAT↑, 1,   MAOA↓, 1,   PSD95↑, 1,   tau↓, 5,   p‑tau↓, 4,   TrkB↑, 1,  

Protein Aggregation

Aβ↓, 16,   BACE↓, 3,   NLRP3↓, 2,  

Drug Metabolism & Resistance

BioAv↓, 15,   BioAv↝, 3,   BioAv↑, 19,   BioEnh↑, 3,   DDS↑, 2,   Dose∅, 1,   Dose↝, 4,   Dose?, 1,   eff↑, 9,   Half-Life↝, 1,   Half-Life↓, 2,   selectivity↑, 1,  

Clinical Biomarkers

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   BMD↑, 1,   creat↓, 1,   CRP↓, 1,   Ferritin↑, 1,   GutMicro↑, 3,   IL6↓, 8,   LDH↓, 1,  

Functional Outcomes

AntiAge↑, 5,   AntiCan↑, 2,   AntiDiabetic↑, 1,   AntiTum↓, 1,   cardioP↑, 1,   chemoPv↑, 1,   cognitive↑, 14,   cognitive∅, 1,   cognitive↝, 1,   GFR↑, 1,   hepatoP↑, 4,   memory↑, 13,   Mood↑, 1,   neuroP↑, 12,   Obesity↓, 1,   OS↑, 3,   radioP↑, 3,   RenoP↑, 2,   toxicity↓, 3,   toxicity∅, 1,   Wound Healing↑, 3,   Wound Healing↓, 1,  

Infection & Microbiome

Bacteria↓, 1,  
Total Targets: 188

Research papers

Year Title Authors PMID Link Flag
2025Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer CellsZeinab Hormozi-MoghaddamPMC12283205https://pmc.ncbi.nlm.nih.gov/articles/PMC12283205/0
2022The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III ExpressionAhlam AlhusainPMC8891863https://pmc.ncbi.nlm.nih.gov/articles/PMC8891863/0
2021Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa CellsSERA KAYACANhttps://ar.iiarjournals.org/content/41/3/12710
2018Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effectsLu XuPMC6206930https://pmc.ncbi.nlm.nih.gov/articles/PMC6206930/0
2015Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cellsPiwen WangPMC4166488https://pmc.ncbi.nlm.nih.gov/articles/PMC4166488/0
2017Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A reviewYingying Jianghttps://www.sciencedirect.com/science/article/abs/pii/S00452068173058490
2017Naturally occurring anti-cancer agents targeting EZH2Fahimeh Shahabipourhttps://www.sciencedirect.com/science/article/abs/pii/S03043835173018420
2020Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid BetaCeyhan Haciogluhttps://link.springer.com/article/10.1007/s12011-020-02511-20
2016Novel evidence for curcumin and boswellic acid induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancerShusuke TodenPMC4417447https://pmc.ncbi.nlm.nih.gov/articles/PMC4417447/0
2015The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activityKarin Linnewiel-Hermoni25711533https://pubmed.ncbi.nlm.nih.gov/25711533/0
2023Anti-cancer Activity of Sustained Release Capsaicin FormulationsJustin C MerrittPMC9510151https://pmc.ncbi.nlm.nih.gov/articles/PMC9510151/0
2025The Combination of Celastrol and Curcumin Enhances the Antitumor Effect in Nasopharyngeal Carcinoma by Inducing FerroptosisTao Fenghttps://www.jstage.jst.go.jp/article/bpb/48/7/48_b25-00053/_html/-char/en0
2022Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and ResveratrolSumio HayakawaPMC9774417https://pmc.ncbi.nlm.nih.gov/articles/PMC9774417/0
2021Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer Xiongjie Zhu 34127219https://pubmed.ncbi.nlm.nih.gov/34127219/0
2018Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysisPriya Yadav29279114https://pubmed.ncbi.nlm.nih.gov/29279114/0
2014Caloric restriction mimetics: natural/physiological pharmacological autophagy inducersGuillermo MariñoPMC4502795https://pmc.ncbi.nlm.nih.gov/articles/PMC4502795/0
2016Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s DiseaseNur Adalier Barlashttps://www.researchgate.net/publication/309452537_Vitamin_E_Turmeric_and_Saffron_in_Treatment_of_Alzheimer's_Disease0
2026Targeting Cancer Stem Cells with Phytochemicals: Molecular Mechanisms and Therapeutic PotentialAshok Kumar Sahhttps://www.mdpi.com/2227-9059/14/1/2150
2026Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical TrialsUshna MomalPMC12865664https://pmc.ncbi.nlm.nih.gov/articles/PMC12865664/0
2025Curcumin Shows Promise in Targeting Colorectal Cancer Stem-like Cells: Mechanistic Insights and Clinical ImplicationsMedXYhttps://news.medxy.ai/curcumin-shows-promise-in-targeting-colorectal-cancer-stem-like-cells-mechanistic-insights-and-clinical-implications/0
2025Curcumin induces IL-6 receptor shedding via the ADAM10 proteinaseToshiyuki Muraihttps://www.sciencedirect.com/science/article/abs/pii/S0006291X250065390
2025Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancerShukur Wasman SmailPMC12657484https://pmc.ncbi.nlm.nih.gov/articles/PMC12657484/0
2025Curcumin as a complementary treatment in oncological therapy: a systematic reviewLisa C. Gutschehttps://link.springer.com/article/10.1007/s00228-024-03764-90
2025Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathwayMuhammad Aminuddin Mohd Shafieehttps://www.nature.com/articles/s41598-025-19874-y0
2025The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic ReviewAmir Mohammad Salehihttps://www.benthamdirect.com/content/journals/mirna/10.2174/01221153663041142409040514290
2025A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailabilityMaurice A.G.M. Kroonhttps://www.cell.com/iscience/fulltext/S2589-0042%2825%2900836-30
2025An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomesSam Khanhttps://www.sciencedirect.com/science/article/pii/S03043835250045370
2025Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's diseaseSafaa M Awad40153089https://pubmed.ncbi.nlm.nih.gov/40153089/0
2025Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical ProspectsDingya SunPMC12788039https://pmc.ncbi.nlm.nih.gov/articles/PMC12788039/0
2025Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic CombinationsKhadija Akter Khadija Akterhttps://www.mdpi.com/1467-3045/47/9/7160
2025Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in miceGaifen LiPMC11706931https://pmc.ncbi.nlm.nih.gov/articles/PMC11706931/0
2024Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?Shadiya Fawzul AmeerPMC11537944https://pmc.ncbi.nlm.nih.gov/articles/PMC11537944/0
2024Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's diseaseKumar Gajendrahttps://www.sciencedirect.com/science/article/pii/S27724174240002680
2024A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics StudyEvdokiya Salamanovahttps://www.ddg-pharmfac.net/ddg/publications_files/2024_Chemistry.pdf0
2024The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer ManagementAndrea AmaroliPMC11275093https://pmc.ncbi.nlm.nih.gov/articles/PMC11275093/0
2024Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activitiesWei-Biao Zanghttps://www.sciencedirect.com/science/article/abs/pii/S02235234230103710
2024Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROSYan WangPMC11615379https://pmc.ncbi.nlm.nih.gov/articles/PMC11615379/0
2024Inhibition of Cancer Stem-like Cells by Curcumin and Other Polyphenol Derivatives in MDA-MB-231 TNBC CellsMaria RosPMC11242520https://pmc.ncbi.nlm.nih.gov/articles/PMC11242520/0
2024Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the EvidenceYandra Cervelim NunesPMC11357524https://pmc.ncbi.nlm.nih.gov/articles/PMC11357524/0
2024Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological StudyViljemka Bučević Popovićhttps://www.mdpi.com/1424-8247/17/2/1640
2024Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and TreatmentCaroline Bertoncini-SilvaPMC10967568https://pmc.ncbi.nlm.nih.gov/articles/PMC10967568/0
2024The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic ReviewGianna Dipalmahttps://air.unimi.it/retrieve/handle/2434/1223982/3272183/antioxidants-13-01160%20%281%29.pdf0
2024Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of FerroptosisYuan ZhangPMC11414380https://pmc.ncbi.nlm.nih.gov/articles/PMC11414380/0
2024Potentiality of Curcumin Against Radio-Chemotherapy Induced Oral Mucositis: A ReviewManoj Kumar SarangiPMC11920569https://pmc.ncbi.nlm.nih.gov/articles/PMC11920569/0
2024Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity RelieveYuhang ChengPMC11826934https://pmc.ncbi.nlm.nih.gov/articles/PMC11826934/0
2024Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathwayChuanjian YuanPMC10903231https://pmc.ncbi.nlm.nih.gov/articles/PMC10903231/0
2024Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and ImplicationsRebecca SeitzPMC11428833https://pmc.ncbi.nlm.nih.gov/articles/PMC11428833/0
2024Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease ManagementDong-Oh MoonPMC10932100https://pmc.ncbi.nlm.nih.gov/articles/PMC10932100/0
2024Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of ActionWamidh H TalibPMC11394730https://pmc.ncbi.nlm.nih.gov/articles/PMC11394730/0
2024Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against CancerChristoffer Briggs LambringPMC10805528https://pmc.ncbi.nlm.nih.gov/articles/PMC10805528/0
2024Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balanceYitian SunPMC11334420https://pmc.ncbi.nlm.nih.gov/articles/PMC11334420/0
2023Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)Ye HuPMC10773205https://pmc.ncbi.nlm.nih.gov/articles/PMC10773205/0
2023Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysisMarten A KhosraviPMC11074217https://pmc.ncbi.nlm.nih.gov/articles/PMC11074217/0
2023Curcumin as a hepatoprotective agent against chemotherapy-induced liver injuryVicenç Ruiz de Porrashttps://www.sciencedirect.com/science/article/pii/S00243205230075430
2023Effects of curcumin and ursolic acid in prostate cancer: A systematic reviewBenjamin D BesasiePMC10976464https://pmc.ncbi.nlm.nih.gov/articles/PMC10976464/0
2023Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical EvidenceZohra Nausheen NizamiPMC10295724https://pmc.ncbi.nlm.nih.gov/articles/PMC10295724/0
2023Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasisChunfeng Liu,https://www.nature.com/articles/s41418-023-01178-10
2023Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signalingWang Xhttps://europepmc.org/article/med/373334860
2023Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinomaMinxiao ChenPMC9851268https://pmc.ncbi.nlm.nih.gov/articles/PMC9851268/0
2023Dual Action of Curcumin as an Anti- and Pro-Oxidant from a Biophysical PerspectiveAgnieszka Wolnicka-Glubiszhttps://www.researchgate.net/publication/373728355_Dual_Action_of_Curcumin_as_an_Anti-_and_Pro-Oxidant_from_a_Biophysical_Perspective0
2023Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical TrialsAjaikumar B KunnumakkaraPMC10111629https://pmc.ncbi.nlm.nih.gov/articles/PMC10111629/0
2023The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancerMohammad ZahediPMC10696979https://pmc.ncbi.nlm.nih.gov/articles/PMC10696979/0
2022Curcumin induces autophagic cell death in human thyroid cancer cellsLi Zhang 34634291https://pubmed.ncbi.nlm.nih.gov/34634291/0
2022Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritisVidhu SethiPMC9511324https://pmc.ncbi.nlm.nih.gov/articles/PMC9511324/0
2022Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessmentPriyashi Raohttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.02690360
2022Curcumin, but not its degradation products, in combination with silibinin is primarily responsible for the inhibition of colon cancer cell proliferationAlhan SayyedPMC9372765https://pmc.ncbi.nlm.nih.gov/articles/PMC9372765/0
2022Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte CellsŞebnem Erfen36342584https://pubmed.ncbi.nlm.nih.gov/36342584/0
2022Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathwayMengjie Li34592340https://pubmed.ncbi.nlm.nih.gov/34592340/0
2022Regulatory Effects of Curcumin on Platelets: An Update and Future DirectionsYaseen HussainPMC9775400https://pmc.ncbi.nlm.nih.gov/articles/PMC9775400/0
2022Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancerRaghavendra S PatwardhanPMC8790659https://pmc.ncbi.nlm.nih.gov/articles/PMC8790659/0
2022Curcumin and colorectal cancer: An update and current perspective on this natural medicineWenhao Wenghttps://www.sciencedirect.com/science/article/abs/pii/S1044579X203004440
2022Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other CancersVasiliki ZoiPMC8869399pmc.ncbi.nlm.nih.gov/articles/PMC8869399/0
2022An update of Nrf2 activators and inhibitors in cancer prevention/promotionFarhad PouremamaliPMC9245222https://pmc.ncbi.nlm.nih.gov/articles/PMC9245222/0
2022Curcumin and Its Derivatives Induce Apoptosis in Human Cancer Cells by Mobilizing and Redox Cycling Genomic Copper IonsMohammed Ahmed Ismail Alhasawihttps://www.mdpi.com/1420-3049/27/21/74100
2021A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative DisordersRumyana SimeonovaPMC8037483https://pmc.ncbi.nlm.nih.gov/articles/PMC8037483/0
2021The effect of Curcumin on multi-level immune checkpoint blockade and T cell dysfunction in head and neck cancerLihua Liu 34592487https://pubmed.ncbi.nlm.nih.gov/34592487/0
2021Cellular uptake and apoptotic properties of gemini curcumin in gastric cancer cellsAli Emami 34623595https://pubmed.ncbi.nlm.nih.gov/34623595/0
2021Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axisLiang PanPMC8290411https://pmc.ncbi.nlm.nih.gov/articles/PMC8290411/0
2021Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axisYing LiangPMC8237388https://pmc.ncbi.nlm.nih.gov/articles/PMC8237388/0
2021Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissuesSha TianPMC7905673https://pmc.ncbi.nlm.nih.gov/articles/PMC7905673/0
2021Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability Meng Jin 34374130https://pubmed.ncbi.nlm.nih.gov/34374130/0
2021Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axisSifan SunPMC8594156https://pmc.ncbi.nlm.nih.gov/articles/PMC8594156/0
2021Molecular mechanisms underlying curcumin-mediated microRNA regulation in carcinogenesis; Focused on gastrointestinal cancersAbolfazl Akbarihttps://www.sciencedirect.com/science/article/pii/S07533322210063140
2021Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling PathwaysHaijun Wanghttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.660712/full0
2021Revealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitorPriyashi RaoPMC8410813https://pmc.ncbi.nlm.nih.gov/articles/PMC8410813/0
2021Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture systemShaymaa Essam El FekyPMC8005724 https://pmc.ncbi.nlm.nih.gov/articles/PMC8005724/0
2021New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer EffectsAndrea ArenaPMC8622305https://pmc.ncbi.nlm.nih.gov/articles/PMC8622305/0
2021Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's DiseaseInes ELBini-DhouibPMC8158738https://pmc.ncbi.nlm.nih.gov/articles/PMC8158738/0
2021Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of CurcuminSahdeo PrasadPMC8268053https://pmc.ncbi.nlm.nih.gov/articles/PMC8268053/0
2021Antiproliferative and ROS Regulation Activity of Photoluminescent Curcumin-Derived NanodotsDurga M Arvapalli35005943https://pubmed.ncbi.nlm.nih.gov/35005943/0
2021Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effectsAsal Jalal Abadi34697839https://pubmed.ncbi.nlm.nih.gov/34697839/0
2021Curcumin suppresses the proliferation of oral squamous cell carcinoma through a specificity protein 1/nuclear factor‑κB‑dependent pathwayTian Liuhttps://www.spandidos-publications.com/10.3892/etm.2021.96350
2021Analysis of Curcumin as a Radiosensitizer in Cancer Therapy with Serum Survivin Examination: Randomised Control TrialYudi Mulyana HidayatPMC8184198https://pmc.ncbi.nlm.nih.gov/articles/PMC8184198/0
2021Counteracting Action of Curcumin on High Glucose-Induced Chemoresistance in Hepatic Carcinoma CellsVivek Kumar Sonihttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.738961/full0
2021Dual Role of Reactive Oxygen Species and their Application in Cancer TherapyRun Huanghttps://www.jcancer.org/v12p5543.htm0
2021Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signalingL Gao 33566305https://pubmed.ncbi.nlm.nih.gov/33566305/0
2021Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer CellsGuoli LiPMC8470329https://pmc.ncbi.nlm.nih.gov/articles/PMC8470329/0
2021Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway Xiaoqing Xu 33684690https://www.sciencedirect.com/science/article/pii/S0753332221002249?via%3Dihub0
2021Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagyXin TangPMC8046146https://pmc.ncbi.nlm.nih.gov/articles/PMC8046146/0
2021Curcumin Reduces Colorectal Cancer Cell Proliferation and Migration and Slows In Vivo Growth of Liver Metastases in RatsBorja Herrero de la PartePMC8467247https://pmc.ncbi.nlm.nih.gov/articles/PMC8467247/0
2021TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional SuppressionChunfeng XiePMC7970191https://pmc.ncbi.nlm.nih.gov/articles/PMC7970191/0
2021Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathwayXiaohong MaoPMC8159825https://pmc.ncbi.nlm.nih.gov/articles/PMC8159825/0
2021Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoidsMohamed Elbadawy34411919https://www.sciencedirect.com/science/article/pii/S075333222100826X?via%3Dihub0
2021Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZYuzhen Zheng 33539684https://pubmed.ncbi.nlm.nih.gov/33539684/0
2021Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS GenerationTomasz KostrzewaPMC8508995 https://pmc.ncbi.nlm.nih.gov/articles/PMC8508995/0
2021Curcumin-Induced Global Profiling of Transcriptomes in Small Cell Lung Cancer CellsFei MoPMC7835540https://pmc.ncbi.nlm.nih.gov/articles/PMC7835540/0
2020The effect of Curcuma longa extract and its active component (curcumin) on gene expression profiles of lipid metabolism pathway in liver cancer cell line (HepG2)Reyhaneh Taebihttps://www.sciencedirect.com/science/article/abs/pii/S24520144193022370
2020Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro ExperimentsChao MaPMC7007779https://pmc.ncbi.nlm.nih.gov/articles/PMC7007779/0
2020Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathwayNaizhi Wanghttps://www.researchgate.net/publication/344026895_Curcumin_inhibits_migration_and_invasion_of_non-small_cell_lung_cancer_cells_through_up-regulation_of_miR-206_and_suppression_of_PI3KAKTmTOR_signaling_pathway0
2020Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cellsTuan WangPMC7545669https://pmc.ncbi.nlm.nih.gov/articles/PMC7545669/0
2020Modification of radiosensitivity by Curcumin in human pancreatic cancer cell linesKatharina SchwarzPMC7052161https://pmc.ncbi.nlm.nih.gov/articles/PMC7052161/0
2020Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockadeYuichi OhnishiPMC7204627https://pmc.ncbi.nlm.nih.gov/articles/PMC7204627/0
2020Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and HybridsEirini ChainoglouPMC7139886https://pmc.ncbi.nlm.nih.gov/articles/PMC7139886/0
2020The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicityFabiola PacielloPMC6978317https://pmc.ncbi.nlm.nih.gov/articles/PMC6978317/0
2020Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell linesNujoud Al-YousefPMC7041105https://pmc.ncbi.nlm.nih.gov/articles/PMC7041105/0
2020Enhanced anti‐tumor effects of the PD‐1 blockade combined with a highly absorptive form of curcumin targeting STAT3Taeko HayakawaPMC7734012https://pmc.ncbi.nlm.nih.gov/articles/PMC7734012/0
2020Curcumin inhibits the growth of triple‐negative breast cancer cells by silencing EZH2 and restoring DLC1 expressionXueliang ZhouPMC7521266https://pmc.ncbi.nlm.nih.gov/articles/PMC7521266/0
2020Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axisLe Liu 32866906https://pubmed.ncbi.nlm.nih.gov/32866906/0
2020Synthesis of novel 4-Boc-piperidone chalcones and evaluation of their cytotoxic activity against highly-metastatic cancer cellsCarlimar Ocasio-MalavéPMC7460386https://pmc.ncbi.nlm.nih.gov/articles/PMC7460386/0
2020Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling PathwaysNiyoosha KandeziPMC7422850https://pmc.ncbi.nlm.nih.gov/articles/PMC7422850/0
2020Neuroprotection by curcumin: A review on brain delivery strategiesAnis Askarizadehhttps://www.sciencedirect.com/science/article/abs/pii/S03785173203046090
2020Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer CellsRuihua LiPMC7691002https://pmc.ncbi.nlm.nih.gov/articles/PMC7691002/0
2020Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cellsJiaqin CaiPMC7673326https://pmc.ncbi.nlm.nih.gov/articles/PMC7673326/0
2020Cell-Type Specific Metabolic Response of Cancer Cells to CurcuminAnamarija MojzešPMC7084320https://pmc.ncbi.nlm.nih.gov/articles/PMC7084320/0
2020Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3pWei HanPMC7519441https://pmc.ncbi.nlm.nih.gov/articles/PMC7519441/0
2020Curcumin may be a potential adjuvant treatment drug for colon cancer by targeting CD44Xu Fan33182071https://pubmed.ncbi.nlm.nih.gov/33182071/0
2020Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cellsGabriel Alvares Borges32628350https://pubmed.ncbi.nlm.nih.gov/32628350/0
2020Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response PathwayRuiying TongPMC7317311https://pmc.ncbi.nlm.nih.gov/articles/PMC7317311/0
2020The inhibitory effect of curcumin via fascin suppression through JAK/STAT3 pathway on metastasis and recurrence of ovary cancer cellsMi Ju Kim PMC7678137https://pmc.ncbi.nlm.nih.gov/articles/PMC7678137/0
2020Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-CateninXiao ZhangPMC7247599https://pmc.ncbi.nlm.nih.gov/articles/PMC7247599/0
2020LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cellsZhi-Hai Zheng 32757174https://pubmed.ncbi.nlm.nih.gov/32757174/0
2020Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stressYanqiong Zeng 33010228https://pubmed.ncbi.nlm.nih.gov/33010228/0
2020Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s DiseaseShi-Yu ChenPMC7188934https://pmc.ncbi.nlm.nih.gov/articles/PMC7188934/0
2020Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer CellsTing ChenPMC7496454https://pmc.ncbi.nlm.nih.gov/articles/PMC7496454/0
2020Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progressYi Lu32887024https://www.sciencedirect.com/science/article/pii/S0753332220305746?via%3Dihub0
2020Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of BadHiroshi Endo32841581https://pubmed.ncbi.nlm.nih.gov/32841581/0
2020Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin ExpressionXinzhou DengPMC7607721https://pmc.ncbi.nlm.nih.gov/articles/PMC7607721/0
2020Curcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1 Vivek Kumar Soni 32325281https://pubmed.ncbi.nlm.nih.gov/32325281/0
2019Curcumin: a potent agent to reverse epithelial-to-mesenchymal transitionAfsane Bahrami30980365https://pubmed.ncbi.nlm.nih.gov/30980365/0
2019A randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivationYoung Hyo Choi30671976https://pubmed.ncbi.nlm.nih.gov/30671976/0
2019Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASNRui Yanghttps://www.sciencedirect.com/science/article/abs/pii/S09277765193054910
2019Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cellsFaezeh Ghasemihttps://www.researchgate.net/publication/334653550_Curcumin_inhibits_NF-kB_and_Wntb-catenin_pathways_in_cervical_cancer_cells0
2019Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathwayAlexandre ValléePMC6647277https://pmc.ncbi.nlm.nih.gov/articles/PMC6647277/0
2019Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMTChenxia Hu31005718https://pubmed.ncbi.nlm.nih.gov/31005718/0
2019Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancerWei Guo30943812https://pubmed.ncbi.nlm.nih.gov/30943812/0
2019The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasisYuyu Yang31154107https://pubmed.ncbi.nlm.nih.gov/31154107/0
2019Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic PathwayPatricia Rodríguez CastañoPMC6770025https://pmc.ncbi.nlm.nih.gov/articles/PMC6770025/0
2019Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell deathPing Chenhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6567416/0
2019Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial CellsNiraj Chaudharyhttps://www.jstage.jst.go.jp/article/bpb/42/3/42_b18-00928/_html/-char/en0
2019Curcumin inhibits proliferation, migration and neointimal formation of vascular smooth muscle via activating miR-22Minghua Zhangahttps://www.tandfonline.com/doi/full/10.1080/13880209.2020.1781904#abstract0
2019Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer CellsShilpa KattaPMC6801832https://pmc.ncbi.nlm.nih.gov/articles/PMC6801832/0
2019Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathwayJiahuan YinPMC6529728https://pmc.ncbi.nlm.nih.gov/articles/PMC6529728/0
2019The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer CellsSeyed Ahmad Hosseini PMC6524349https://pmc.ncbi.nlm.nih.gov/articles/PMC6524349/0
2019Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK PathwayHua YuPMC6732852https://pmc.ncbi.nlm.nih.gov/articles/PMC6732852/0
2019Biochemical and cellular mechanism of protein kinase CK2 inhibition by deceptive curcuminGiorgio Cozzahttps://febs.onlinelibrary.wiley.com/doi/10.1111/febs.151110
2019Iron chelation by curcumin suppresses both curcumin-induced autophagy and cell death together with iron overload neoplastic transformationNathan E RaineyPMC6901436https://pmc.ncbi.nlm.nih.gov/articles/PMC6901436/0
2019Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics studyLakshya Mittal31518962https://pubmed.ncbi.nlm.nih.gov/31518962/0
2019Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell lineHsing-Yu YenPMC6872918https://pmc.ncbi.nlm.nih.gov/articles/PMC6872918/0
2019Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cellsLi-Dong Liu 31006841https://pubmed.ncbi.nlm.nih.gov/31006841/0
2019Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau HyperphosphorylationTushar Kanti DasPMC6839535https://pmc.ncbi.nlm.nih.gov/articles/PMC6839535/0
2019Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cellsVictor Aedo-Aguilera 31436299https://pubmed.ncbi.nlm.nih.gov/31436299/0
2019The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro Frederik RoosPMC6432698https://pmc.ncbi.nlm.nih.gov/articles/PMC6432698/0
2019Stem Cell Therapy: Curcumin Does the TrickSimin Sharifi31452263https://pubmed.ncbi.nlm.nih.gov/31452263/0
2019Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro AssayAimi Syamima Abdul ManapPMC6718453https://pmc.ncbi.nlm.nih.gov/articles/PMC6718453/0
2019Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer CellsChunlin Sun 31539270https://pubmed.ncbi.nlm.nih.gov/31539270/0
2019The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?Shusuke TodenPMC6424351https://pmc.ncbi.nlm.nih.gov/articles/PMC6424351/0
2019The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studiesS.D. Voulgaropoulouhttps://www.sciencedirect.com/science/article/pii/S000689931930530X0
2019Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer CellsGamze Güney Eskiler 31287789https://pubmed.ncbi.nlm.nih.gov/31287789/0
2019Curcumin Acts as Post-protective Effects on Rat Hippocampal Synaptosomes in a Neuronal Model of Aluminum-Induced ToxicityFatih Kar31264110https://pubmed.ncbi.nlm.nih.gov/31264110/0
2018Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cellsLianhua ZhangPMC6017220https://pmc.ncbi.nlm.nih.gov/articles/PMC6017220/0
2018Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of actionWamidh H TalibPMC6276637https://pmc.ncbi.nlm.nih.gov/articles/PMC6276637/0
2018Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibitionFarid Ahmad SiddiquiPMC5974195https://pmc.ncbi.nlm.nih.gov/articles/PMC5974195/0
2018Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signalingBiqiong Ren 29901164https://pubmed.ncbi.nlm.nih.gov/29901164/0
2018Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancerHisamitsu IdePMC5891173https://pmc.ncbi.nlm.nih.gov/articles/PMC5891173/0
2018Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathwayFurong Liu29328421https://pubmed.ncbi.nlm.nih.gov/29328421/0
2018Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells29374713https://pubmed.ncbi.nlm.nih.gov/29374713/0
2018Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder CancerKai Wang 30149755https://pubmed.ncbi.nlm.nih.gov/30149755/0
2018Anticancer effect of curcumin on breast cancer and stem cellsHui-Tien Liuhttps://www.sciencedirect.com/science/article/pii/S22134530183005330
2018Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal CarcinomaAmir Abbas Momtazi-Borojeni29788875https://pubmed.ncbi.nlm.nih.gov/29788875/0
2018Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulationWanli Zhao29485738https://www.researchgate.net/publication/323436442_Curcumin_suppressed_the_prostate_cancer_by_inhibiting_JNK_pathways_via_epigenetic_regulation0
2018Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signalingHongbing Fu28926094https://pubmed.ncbi.nlm.nih.gov/28926094/0
2018Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cellsAjda Coker-Gurkan29770869https://pubmed.ncbi.nlm.nih.gov/29770869/0
2018Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanismLeeseon KimPMC6431345https://pmc.ncbi.nlm.nih.gov/articles/PMC6431345/0
2018Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease TreatmentRafaela PeronPMC5874708https://pmc.ncbi.nlm.nih.gov/articles/PMC5874708/0
2018Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's DiseaseP Hemachandra Reddy29332042https://pubmed.ncbi.nlm.nih.gov/29332042/0
2018Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation Hung-Hua Liang 30056019https://pubmed.ncbi.nlm.nih.gov/30056019/0
2018Curcumin inhibits proliferation and promotes apoptosis of breast cancer cellsShan HuPMC6090267https://pmc.ncbi.nlm.nih.gov/articles/PMC6090267/0
2018Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month TrialGary W Small29246725https://pubmed.ncbi.nlm.nih.gov/29246725/0
2017Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog PathwaysJian-Yun Zhu28198062https://pubmed.ncbi.nlm.nih.gov/28198062/0
2017Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAsJames A. McCubreyhttps://www.aging-us.com/article/101250/text0
2017Hepatoprotective Effect of Curcumin on Hepatocellular Carcinoma Through Autophagic and Apoptic PathwaysAhmed M. Elmansihttps://www.sciencedirect.com/science/article/pii/S16652681193109930
2017The metalloproteinase ADAM10: A useful therapeutic target?Sebastian Wetzelhttps://www.sciencedirect.com/science/article/pii/S016748891730157X0
2017Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti‐lung cancer cell invasionJian‐wei ZhanPMC5582578https://pmc.ncbi.nlm.nih.gov/articles/PMC5582578/0
2017Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseasesJames A McCubrey28579298https://pubmed.ncbi.nlm.nih.gov/28579298/0
2017Screening for Circulating Tumour Cells Allows Early Detection of Cancer and Monitoring of Treatment Effectiveness: An Observational StudyPMC5697492https://pmc.ncbi.nlm.nih.gov/articles/PMC5697492/0
2017Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cellsMariela RiveraPMC5476315https://pmc.ncbi.nlm.nih.gov/articles/PMC5476315/0
2017Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axisHongwen Cao28391351https://pubmed.ncbi.nlm.nih.gov/28391351/0
2017Combination therapy in combating cancerReza Bayat MokhtariPMC5514969https://pmc.ncbi.nlm.nih.gov/articles/PMC5514969/0
2017Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cellsAida Rodriguez-Garcia28391184https://pubmed.ncbi.nlm.nih.gov/28391184/0
2017Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelationChunguang YangPMC5317247https://pmc.ncbi.nlm.nih.gov/articles/PMC5317247/0
2017Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancerSaswati BanerjeePMC5545125https://pmc.ncbi.nlm.nih.gov/articles/PMC5545125/0
2017Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer CellsMinxiao Chen27990666https://pubmed.ncbi.nlm.nih.gov/27990666/0
2017Long-term stabilisation of myeloma with curcuminDr Abbas Zaidi,https://casereports.bmj.com/content/2017/bcr-2016-2181480
2017Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stressWang Liao https://www.sciencedirect.com/science/article/abs/pii/S07533322173114720
2017Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130aHuiqiang DouPMC5705620https://pmc.ncbi.nlm.nih.gov/articles/PMC5705620/0
2017Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretionShufen ZhouPMC5537064https://pmc.ncbi.nlm.nih.gov/articles/PMC5537064/0
2017Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cellsXue WangPMC5505128https://pmc.ncbi.nlm.nih.gov/articles/PMC5505128/0
2017Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activitySundarraj Jayakumar29080841https://pubmed.ncbi.nlm.nih.gov/29080841/0
2017The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancerJingna Su 28535906https://pubmed.ncbi.nlm.nih.gov/28535906/0
2017Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathwayDeying YangPMC5529934https://pmc.ncbi.nlm.nih.gov/articles/PMC5529934/0
2016Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic MiceKunmu Zhenghttps://link.springer.com/article/10.1007/s12035-016-9802-90
2016Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathwayLei Caohttps://www.spandidos-publications.com/or/35/6/37280
2016Relationship and interactions of curcumin with radiation therapyVivek VermaPMC4896895https://pmc.ncbi.nlm.nih.gov/articles/PMC4896895/0
2016Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cellsMingming Zhu31042325https://pubmed.ncbi.nlm.nih.gov/31042325/0
2016Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cellsDevbrat Kumar27261574https://pubmed.ncbi.nlm.nih.gov/27261574/0
2016Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic AcidDharmendra Kumar KhatriPMC4883067https://pmc.ncbi.nlm.nih.gov/articles/PMC4883067/0
2016Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled StudyJalal Hejazihttps://www.researchgate.net/publication/290597698_Effect_of_Curcumin_Supplementation_During_Radiotherapy_on_Oxidative_Status_of_Patients_with_Prostate_Cancer_A_Double_Blinded_Randomized_Placebo-Controlled_Study0
2016Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signalingJian Sha27657825https://pubmed.ncbi.nlm.nih.gov/27657825/0
2016Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductaseSundarraj Jayakumar27381867https://pubmed.ncbi.nlm.nih.gov/27381867/0
2015Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancerJiayi YangPMC4583908https://pmc.ncbi.nlm.nih.gov/articles/PMC4583908/0
2015Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signalingYuefeng DuPMC4665143https://pmc.ncbi.nlm.nih.gov/articles/PMC4665143/ 0
2015Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of CurcuminTianhui NiuPMC4575166https://pmc.ncbi.nlm.nih.gov/articles/PMC4575166/0
2015Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cellsPeter P Sordillo25667437https://pubmed.ncbi.nlm.nih.gov/25667437/0
2015Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cellsXiuhua ZhangPMC4636884https://pmc.ncbi.nlm.nih.gov/articles/PMC4636884/0
2015Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitroKe Wang25229889https://pubmed.ncbi.nlm.nih.gov/25229889/0
2015Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenograftsJeong Hee HongPMC4565901https://pmc.ncbi.nlm.nih.gov/articles/PMC4565901/0
2015Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signalingSeyung S ChungPMC4290892https://pmc.ncbi.nlm.nih.gov/articles/PMC4290892/0
2015Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trialsAmirhossein Sahebkarhttps://www.sciencedirect.com/science/article/pii/S17564646150000920
2015Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stressWei-Jiunn LeePMC4445067https://pmc.ncbi.nlm.nih.gov/articles/PMC4445067/0
2015Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-CJing LiPMC4446835https://pmc.ncbi.nlm.nih.gov/articles/PMC4446835/0
2015Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacyThamil Selvee RamasamyPMC4599442https://pmc.ncbi.nlm.nih.gov/articles/PMC4599442/0
2015Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell linesPUTERI BAHARUDDINPMC4699625https://pmc.ncbi.nlm.nih.gov/articles/PMC4699625/0
2015Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathwayLICHuAN Wuhttps://www.spandidos-publications.com/10.3892/or.2015.4279/download0
2015Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cellsDae-Woon EomPMC4576954https://pmc.ncbi.nlm.nih.gov/articles/PMC4576954/0
2015Anti-cancer activity of curcumin loaded nanoparticles in prostate cancerMurali M YallapuPMC4220612https://pmc.ncbi.nlm.nih.gov/articles/PMC4220612/0
2014Curcumin: a promising agent targeting cancer stem cellsShufei Zang24851881https://pubmed.ncbi.nlm.nih.gov/24851881/0
2014Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenograftsXiao-Ling Yu24606484https://pubmed.ncbi.nlm.nih.gov/24606484/0
2014Comparative absorption of curcumin formulationsRalf JägerPMC3918227https://pmc.ncbi.nlm.nih.gov/articles/PMC3918227/0
2014Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in VivoThambi DoraiPMC4060744https://pmc.ncbi.nlm.nih.gov/articles/PMC4060744/0
2014Oxidative Metabolites of Curcumin Poison Human Type II TopoisomerasesAdam C KetronPMC3541001https://pmc.ncbi.nlm.nih.gov/articles/PMC3541001/0
2014Flavonoid-induced glutathione depletion: Potential implications for cancer treatmentRemy KachadourianPMC3983951https://pmc.ncbi.nlm.nih.gov/articles/PMC3983951/0
2014Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activationDai-Ying Zhou25060817https://pubmed.ncbi.nlm.nih.gov/25060817/0
2014Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stressDexiang Liu24914461https://pubmed.ncbi.nlm.nih.gov/24914461/0
2014Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signalingSung Min NamPMC4060834https://pmc.ncbi.nlm.nih.gov/articles/PMC4060834/0
2014Curcumin and lung cancer--a reviewHiren J Mehta24840628https://pubmed.ncbi.nlm.nih.gov/24840628/0
2014Targeting cancer stem cells by curcumin and clinical applicationsYanyan Li24463298https://pubmed.ncbi.nlm.nih.gov/24463298/0
2013Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAKXiao Guo22711297https://pubmed.ncbi.nlm.nih.gov/22711297/0
2013Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatmentDongxu Kang23353183https://pubmed.ncbi.nlm.nih.gov/23353183/0
2013Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasisTai-Shan Cheng23466486https://pubmed.ncbi.nlm.nih.gov/23466486/0
2013Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcuminAugust BerndPMC3928504https://pmc.ncbi.nlm.nih.gov/articles/PMC3928504/0
2013Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptorHui Guo23875250https://pubmed.ncbi.nlm.nih.gov/23875250/0
2013Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer CellsPMC3730333https://pmc.ncbi.nlm.nih.gov/articles/PMC3730333/0
2013Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and VivoWen‐Zhong Duhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6493544/0
2013Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal CancerChun-Chieh ChenPMC3736531https://pmc.ncbi.nlm.nih.gov/articles/PMC3736531/0
2013Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkersBharat B AggarwalPMC3753829https://pmc.ncbi.nlm.nih.gov/articles/PMC3753829/0
2012Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cellsWenqing Cai22634334https://pubmed.ncbi.nlm.nih.gov/22634334/0
2012Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled studyJohn M RingmanPMC3580400https://pmc.ncbi.nlm.nih.gov/articles/PMC3580400/0
2012Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2Peter H Killian23042094https://pubmed.ncbi.nlm.nih.gov/23042094/0
2011Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP CellsLimin ShuPMC3231852https://pmc.ncbi.nlm.nih.gov/articles/PMC3231852/0
2011Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferationAmmad Ahmad Farooqi 22070051https://pubmed.ncbi.nlm.nih.gov/22070051/0
2011Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitroShuanglin Liu21823017https://pubmed.ncbi.nlm.nih.gov/21823017/0
2011Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studiesMinggui Yuanhttps://www.researchgate.net/publication/49758037_Identification_of_curcumin_derivatives_as_human_glyoxalase_I_inhibitors_A_combination_of_biological_evaluation_molecular_docking_3D-QSAR_and_molecular_dynamics_simulation_studies0
2011Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cellsPrashanthi JavvadiPMC2831122https://pmc.ncbi.nlm.nih.gov/articles/PMC2831122/0
2010N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cellsI-Lun Hsinhttps://www.x-mol.net/paper/article/21463510
2010Epigenetic targets of bioactive dietary components for cancer prevention and therapySyed M MeeranPMC3024548https://pmc.ncbi.nlm.nih.gov/articles/PMC3024548/#Sec110
2010Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cellsH Y Choi20680030https://pubmed.ncbi.nlm.nih.gov/20680030/0
2010Inhibition of NF B and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulationIndira Jutooruhttps://www.researchgate.net/publication/44664092_Inhibition_of_NF_B_and_Pancreatic_Cancer_Cell_and_Tumor_Growth_by_Curcumin_Is_Dependent_on_Specificity_Protein_Down-regulation0
2010Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondriaAshley L Hilchie20358476https://pubmed.ncbi.nlm.nih.gov/20358476/0
2010Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysisMing Liuhttps://www.semanticscholar.org/paper/Binding-of-curcumin-with-glyoxalase-I%3A-Molecular-Liu-Yuan/71d6e398dbf5f7c92ad4b2d5232199e908a98a770
2010Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organsAjay Goel20924967https://pubmed.ncbi.nlm.nih.gov/20924967/0
2010Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigenHisamitsu Ide20503397https://pubmed.ncbi.nlm.nih.gov/20503397/0
2010Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neuronsRui Wang19879308https://pubmed.ncbi.nlm.nih.gov/19879308/0
2010Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cellsMaha H Elamin20025076https://pubmed.ncbi.nlm.nih.gov/20025076/0
2009Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancerJ Shaikh19491009https://pubmed.ncbi.nlm.nih.gov/19491009/0
2008Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitorsXu Qiu18678491https://pubmed.ncbi.nlm.nih.gov/18678491/0
2008NEUROPROTECTIVE EFFECTS OF CURCUMINGreg M ColePMC2527619https://pmc.ncbi.nlm.nih.gov/articles/PMC2527619/0
2008Inhibition of thioredoxin reductase by curcumin analogsZhong Liu18685195https://pubmed.ncbi.nlm.nih.gov/18685195/0
2008Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitroGang Deng18390174https://pubmed.ncbi.nlm.nih.gov/18390174/0
2008Curcumin Inhibits Glyoxalase 1—A Possible Link to Its Anti-Inflammatory and Anti-Tumor ActivityThore SantelPMC2567432https://pmc.ncbi.nlm.nih.gov/articles/PMC2567432/0
2008The effect of curcumin (turmeric) on Alzheimer's disease: An overviewShrikant MishraPMC2781139https://pmc.ncbi.nlm.nih.gov/articles/PMC2781139/0
2008Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesisSharmila ShankarPMC2249593https://pmc.ncbi.nlm.nih.gov/articles/PMC2249593/0
2008Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanismSiwang YuPMC2596943https://pmc.ncbi.nlm.nih.gov/articles/PMC2596943/0
2007Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cellsLarisa Nonn17151092https://pubmed.ncbi.nlm.nih.gov/17151092/0
2007The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 miceKenichi Kitani17516143https://pubmed.ncbi.nlm.nih.gov/17516143/0
2007Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible lightJadranka Dujic17410200https://pubmed.ncbi.nlm.nih.gov/17410200/0
2007Curcumin Induces High Levels of Topoisomerase I− and II−DNA Complexes in K562 Leukemia CellsMiguel López-Lázarohttps://pubs.acs.org/doi/10.1021/np070332i0
2007Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)Santosh K. Sandurhttps://www.sciencedirect.com/science/article/abs/pii/S08915849070032550
2007Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 PathwayMao Lihttps://aacrjournals.org/cancerres/article/67/5/1988/534039/Curcumin-a-Dietary-Component-Has-Anticancer0
2006Curcumin-Artemisinin Combination Therapy for MalariaDalavaikodihalli Nanjaiah Nandakumarhttps://journals.asm.org/doi/full/10.1128/aac.50.5.1859-1860.20060
2006The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivoJ H Hong16389264https://pubmed.ncbi.nlm.nih.gov/16389264/0
2005Use of cancer chemopreventive phytochemicals as antineoplastic agents Maurizio D'Incalci 16257798https://pubmed.ncbi.nlm.nih.gov/16257798/0
2004Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2 Christine Syng-aihttps://aacrjournals.org/mct/article/3/9/1101/234394/Effect-of-curcumin-on-normal-and-tumor-cells-Role0
2002Curcumin down-regulates AR gene expression and activation in prostate cancer cell linesKeiichiro Nakamura12239622https://pubmed.ncbi.nlm.nih.gov/12239622/0
2001The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouseGiselle P LimPMC6762797https://pmc.ncbi.nlm.nih.gov/articles/PMC6762797/0
1999Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signalingBukhtiar H Shahhttps://www.sciencedirect.com/science/article/abs/pii/S00062952990020630
1998Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteersG Shoba9619120https://pubmed.ncbi.nlm.nih.gov/9619120/0
1995Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)Sanjaya Singhhttps://www.jbc.org/article/S0021-9258%2818%2987080-6/fulltext0
2015Antimutagenic Effect of the Ellagic Acid and Curcumin CombinationsZoubková Hhttps://www.hilarispublisher.com/open-access/antimutagenic-effect-of-the-ellagic-acid-and-curcumin-combinations-2161-0525-1000296.pdf0
2007The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcuminRose Hayeshihttps://www.sciencedirect.com/science/article/abs/pii/S02786915060024070
2024Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic TargetsWamidh H TalibPMC10976257https://pmc.ncbi.nlm.nih.gov/articles/PMC10976257/0
2020The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and GenisteinCord Naujokathttps://www.researchgate.net/publication/339583519_The_Big_Five_Phytochemicals_Targeting_Cancer_Stem_Cells_Curcumin_EGCG_Sulforaphane_Resveratrol_and_Genistein0
2018Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods MatterGregory HaskinPMC6380985https://pmc.ncbi.nlm.nih.gov/articles/PMC6380985/0
2019The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic MiceMichiaki Okuda31582657https://pubmed.ncbi.nlm.nih.gov/31582657/0
2013Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cellsHilary M CollinsPMC3583671https://pmc.ncbi.nlm.nih.gov/articles/PMC3583671/0
2012Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cellsMansi A ParasramkaPMC3366245https://pmc.ncbi.nlm.nih.gov/articles/PMC3366245/0
2001Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cellsM H Pan11312881https://pubmed.ncbi.nlm.nih.gov/11312881/0
2022Targeting cancer stem cells by nutraceuticals for cancer therapyMan Chuhttps://www.sciencedirect.com/science/article/abs/pii/S1044579X210020290
2010Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancerAnna Slusarz20395211https://pubmed.ncbi.nlm.nih.gov/20395211/0
2020Thioredoxin-dependent system. Application of inhibitorsAnna Jastrząbhttps://www.tandfonline.com/doi/full/10.1080/14756366.2020.1867121#abstract0
2014Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer CellsAditi MathurPMC4133210https://pmc.ncbi.nlm.nih.gov/articles/PMC4133210/0
2022Synthetic Pathways and the Therapeutic Potential of Quercetin and CurcuminAseel Ali HasanPMC9696847https://pmc.ncbi.nlm.nih.gov/articles/PMC9696847/0
2016Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcuminVikas Sharma27132804https://pubmed.ncbi.nlm.nih.gov/27132804/0
2014Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal AbsorptionKaleb C. Lund, PhDhttps://restorativemedicine.org/wp-content/uploads/2014/04/Combination-Effects-of-Quercetin-Resveratrol-and-Curcumin.pdf0
2006Anti- and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period methodSeiichiro Fujisawa16433026https://pubmed.ncbi.nlm.nih.gov/16433026/0
2014Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cellsMargherita Piccolella24184124https://pubmed.ncbi.nlm.nih.gov/24184124/0
2025Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical modelsAnkita Thakurhttps://www.sciencedirect.com/science/article/abs/pii/S29501997250030390
2025Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrolMohamed AhmedPMC12225039https://pmc.ncbi.nlm.nih.gov/articles/PMC12225039/0
2023The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing miceChenchen Lihttps://www.nature.com/articles/s41598-023-39279-z0
2023The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing miceChenchen LiPMC10432483https://pmc.ncbi.nlm.nih.gov/articles/PMC10432483/0
2019Development of Acetylcholinesterase (AChE) Inhibitorhttps://www.ukessays.com/essays/sciences/development-of-acetylcholinesterase-ache-inhibitor.php0
2021Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal TransitionYongmei ZhaoPMC7843432https://pmc.ncbi.nlm.nih.gov/articles/PMC7843432/0
2026Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination TherapyFarid MortazaviPMC12883924https://pmc.ncbi.nlm.nih.gov/articles/PMC12883924/0
2024Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery SystemsBianca Sânziana DarabanPMC11397357https://pmc.ncbi.nlm.nih.gov/articles/PMC11397357/0
2024Curcumin-Modified Selenium Nanoparticles Improve S180 Tumour Therapy in Mice by Regulating the Gut Microbiota and ChemotherapyRong Zhanghttps://www.tandfonline.com/doi/full/10.2147/IJN.S4766860
2019A novel synthesis of selenium nanoparticles encapsulated PLGA nanospheres with curcumin molecules for the inhibition of amyloid β aggregation in Alzheimer's diseaseXinlong Huo30504054https://pubmed.ncbi.nlm.nih.gov/30504054/0
2022Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer TreatmentIqra SarfrazPMC9609560https://pmc.ncbi.nlm.nih.gov/articles/PMC9609560/0
2015Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer CellsHuarong HuangPMC4668011https://pmc.ncbi.nlm.nih.gov/articles/PMC4668011/0
2020Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signallingMajed Al Fayihttps://www.tandfonline.com/doi/full/10.1080/1061186X.2020.17221360
2017Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolismAlessia LodiPMC5705091https://pmc.ncbi.nlm.nih.gov/articles/PMC5705091/0