tbResList Print — GB gefitinib, erlotinib

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Product

GB gefitinib, erlotinib
Description: <b>selectively</b> targeting the mutant proteins in malignant cells. <br>
epidermal growth factor receptor (EGFR) inhibitors (lung cancer)<br>

Pathway results for Effect on Cancer / Diseased Cells

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,  

Core Metabolism/Glycolysis ⓘ

S6K↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

miR-205↑, 1,   miR-218↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   Let-7↑, 1,  

Migration ⓘ

miR-200b↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2019Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell deathPing Chen—https://pmc.ncbi.nlm.nih.gov/articles/PMC6567416/0
2019Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAsMohd FarhanPMC6413107https://pmc.ncbi.nlm.nih.gov/articles/PMC6413107/0