| Year | Title | Authors | PMID | Link | Flag |
|---|---|---|---|---|---|
| 2015 | Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells | Piwen Wang | PMC4166488 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4166488/ | 0 |
| 2008 | Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence | Harald Hoensch | PMC2703843 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2703843/ | 0 |
| 2017 | Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review | Yingying Jiang | — | https://www.sciencedirect.com/science/article/abs/pii/S0045206817305849 | 0 |
| 2022 | An update of Nrf2 activators and inhibitors in cancer prevention/promotion | Farhad Pouremamali | PMC9245222 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9245222/ | 0 |
| 2015 | Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling | Seyung S Chung | PMC4290892 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4290892/ | 0 |
| 2015 | Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells | Dae-Woon Eom | PMC4576954 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4576954/ | 0 |
| 2011 | Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferation | Ammad Ahmad Farooqi | 22070051 | https://pubmed.ncbi.nlm.nih.gov/22070051/ | 0 |
| 2025 | Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential | Lucia Capasso | — | https://www.researchgate.net/publication/388669154_Epigallocatechin_Gallate_EGCG_Pharmacological_Properties_Biological_Activities_and_Therapeutic_Potential | 0 |
| 2025 | The Role of ER Stress and the Unfolded Protein Response in Cancer | ROSE GHEMRAWI | — | https://cgp.iiarjournals.org/content/22/3/363 | 0 |
| 2025 | Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential | Lucia Capasso | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC11821029/ | 0 |
| 2025 | Nano-Engineered Epigallocatechin Gallate (EGCG) Delivery Systems: Overcoming Bioavailability Barriers to Unlock Clinical Potential in Cancer Therapy | Mohammad Qutub | — | https://link.springer.com/article/10.1208/s12249-025-03145-0 | 0 |
| 2024 | Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer | Shun Wang | — | https://cancerci.biomedcentral.com/articles/10.1186/s12935-024-03391-5 | 0 |
| 2024 | EGCG inhibits diabetic nephrophathy through up regulation of PKM2 | genomediscovery.org | — | https://genomediscovery.org/mmolecular-therapy-for-diabetic-nephropathy-dn-epigallocatechin-egcg-isolated-from-green-tea-increases-pyruvate-kinase-m2-pkm2-expression-decreases-toxic-glucose-metabolites-mitoc/ | 0 |
| 2024 | The Potential of Epigallocatechin Gallate in Targeting Cancer Stem Cells: A Comprehensive Review | Rupa Chaudhuri | 38243984 | https://pubmed.ncbi.nlm.nih.gov/38243984/ | 0 |
| 2024 | Immunomodulatory Effects of Green Tea Catechins and Their Ring Fission Metabolites in a Tumor Microenvironment Perspective | Emmanuele D S Andrade | PMC11478201 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11478201/ | 0 |
| 2024 | EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway | Ho Woon Lee | — | https://www.sciencedirect.com/science/article/pii/S0167488924000028 | 0 |
| 2024 | Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the TXNIP/NLRP3/IL‐1β Signaling Pathway | Yinghui Wang | PMC11666909 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11666909/ | 0 |
| 2024 | Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets | Wamidh H Talib | PMC10976257 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10976257/ | 0 |
| 2024 | Green Tea Epigallocatechin 3-Gallate Reduced Platelet Aggregation and Improved Anticoagulant Proteins in Patients with Transfusion-Dependent β-Thalassemia: A Randomized Placebo-Controlled Clinical Trial | Touchwin Petiwathayakorn | PMC11640449 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11640449/ | 0 |
| 2023 | Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity | Hiroki Tanabe | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC9862901/ | 0 |
| 2023 | The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment | Víctor Marín | PMC10341956 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10341956/ | 0 |
| 2023 | Epigallocatechin-3-gallate and cancer: focus on the role of microRNAs | Chunguang Wang | — | https://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03081-8 | 0 |
| 2023 | Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns | Guichun Wang | — | https://cancerci.biomedcentral.com/articles/10.1186/s12935-023-03161-9 | 0 |
| 2023 | Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications | Mateusz Kciuk | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC10343677/pdf/molecules-28-05246.pdf | 0 |
| 2023 | Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation | Yu Wang | — | https://www.researchgate.net/publication/370713821_Improving_the_anti-tumor_effect_of_EGCG_in_colorectal_cancer_cells_by_blocking_EGCG-induced_YAP_activation | 0 |
| 2023 | Epigallocatechin-3-gallate restores mitochondrial homeostasis impairment by inhibiting HDAC1-mediated NRF1 histone deacetylation in cardiac hypertrophy | Gu Li | — | https://link.springer.com/article/10.1007/s11010-023-04768-2 | 0 |
| 2023 | Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids | Md Soriful Islam | 2023 | https://www.nature.com/articles/s41598-023-35212-6 | 0 |
| 2023 | EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement | Amit Sehgal | — | https://www.sciencedirect.com/science/article/pii/S2667137923000255 | 0 |
| 2023 | The Effects of Green Tea Catechins in Hematological Malignancies | Fernanda Isabel Della Via | PMC10385775 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10385775/ | 0 |
| 2023 | Epigallocatechin-3-Gallate Prevents the Acquisition of a Cancer Stem Cell Phenotype in Ovarian Cancer Tumorspheres through the Inhibition of Src/JAK/STAT3 Signaling | Sahily Rodriguez Torres | — | https://www.mdpi.com/2227-9059/11/4/1000 | 0 |
| 2023 | Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies | Xin-Yu Wei | PMC10462709 | https://pmc.ncbi.nlm.nih.gov/articles/PMC10462709/ | 0 |
| 2022 | Antioxidation Function of EGCG by Activating Nrf2/HO-1 Pathway in Mice with Coronary Heart Disease | Xiaoyi Huang | PMC9293516 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9293516/ | 0 |
| 2022 | The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review | Elena Ferrari | — | https://www.researchgate.net/publication/360934968_The_Potential_of_Epigallocatechin_Gallate_EGCG_in_Targeting_Autophagy_for_Cancer_Treatment_A_Narrative_Review | 0 |
| 2022 | When Natural Compounds Meet Nanotechnology: Nature-Inspired Nanomedicines for Cancer Immunotherapy | Linna Yu | — | https://www.researchgate.net/publication/362395636_When_Natural_Compounds_Meet_Nanotechnology_Nature-Inspired_Nanomedicines_for_Cancer_Immunotherapy | 0 |
| 2022 | Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells | Phuriwat Khiewkamro | PMC9063442 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9063442/ | 0 |
| 2022 | EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress | Wenbing Wu | — | https://onlinelibrary.wiley.com/doi/full/10.1155/2022/7099589 | 0 |
| 2022 | Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation | Ju Hyung Seok | PMC9523342 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9523342/ | 0 |
| 2022 | EGCG-coated silver nanoparticles self-assemble with selenium nanowires for treatment of drug-resistant bacterial infections by generating ROS and disrupting biofilms | Chenhao Yang | — | https://www.semanticscholar.org/paper/EGCG-coated-silver-nanoparticles-self-assemble-with-Yang-Wang/36ea7fc4cf689f9c6637599e8374ae35fdaef86f | 0 |
| 2022 | Epigallocatechin-3-gallate Delivered in Nanoparticles Increases Cytotoxicity in Three Breast Carcinoma Cell Lines | Fulvia Farabegoli | — | https://pubs.acs.org/doi/10.1021/acsomega.2c01829# | 0 |
| 2022 | Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro | Paul M Seidler | PMC9481533 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9481533/ | 0 |
| 2022 | Laminin Receptor-Mediated Nanoparticle Uptake by Tumor Cells: Interplay of Epigallocatechin Gallate and Magnetic Force at Nano-Bio Interface | Sheng-Chieh Hsu | PMC9330565 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9330565/ | 0 |
| 2022 | Identification of plant-based hexokinase 2 inhibitors: combined molecular docking and dynamics simulation studies | Asifa Khan | 34176437 | https://pubmed.ncbi.nlm.nih.gov/34176437/ | 0 |
| 2022 | Characterization of mesenchymal stem cells with augmented internalization of magnetic nanoparticles: The implication of therapeutic potential | Ching-Hui Chien | — | https://www.sciencedirect.com/science/article/abs/pii/S0304885322009453 | 0 |
| 2021 | Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats | Shanji Nan | PMC8128347 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8128347/ | 0 |
| 2021 | Flavonoids Targeting HIF-1: Implications on Cancer Metabolism | Marek Samec | PMC7794792 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7794792/ | 0 |
| 2021 | Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex | Omeima Abdullah | PMC8143546 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8143546/ | 0 |
| 2021 | Simple Approach to Enhance Green Tea Epigallocatechin Gallate Stability in Aqueous Solutions and Bioavailability: Experimental and Theoretical Characterizations | Philippe-Henri Secretan | PMC8706847 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8706847/ | 0 |
| 2020 | Bioavailability of Epigallocatechin Gallate Administered With Different Nutritional Strategies in Healthy Volunteers | Vicente Andreu-Fernández | — | https://www.researchgate.net/publication/341598633_Bioavailability_of_Epigallocatechin_Gallate_Administered_With_Different_Nutritional_Strategies_in_Healthy_Volunteers | 0 |
| 2020 | Advanced Nanovehicles-Enabled Delivery Systems of Epigallocatechin Gallate for Cancer Therapy | Kai Li | PMC7645157 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7645157/ | 0 |
| 2020 | Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways | Madhumitha Kedhari Sundaram | PMC7584697 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7584697/ | 0 |
| 2020 | The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein | Cord Naujokat | — | https://www.researchgate.net/publication/339583519_The_Big_Five_Phytochemicals_Targeting_Cancer_Stem_Cells_Curcumin_EGCG_Sulforaphane_Resveratrol_and_Genistein | 0 |
| 2020 | Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells | Oskar Ciesielski | PMC7287656 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7287656/ | 0 |
| 2020 | Epigallocatechin Gallate (EGCG) | — | https://www.alzforum.org/therapeutics/epigallocatechin-gallate-egcg | 0 | |
| 2020 | Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer | Mehdi Sharifi-Rad | — | https://www.researchgate.net/publication/338741198_Preclinical_Pharmacological_Activities_of_Epigallocatechin-3-gallate_in_Signaling_Pathways_An_Update_on_Cancer | 0 |
| 2020 | Prooxidant Effects of Epigallocatechin-3-Gallate in Health Benefits and Potential Adverse Effect | Jie Ouyang | PMC7441425 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7441425/ | 0 |
| 2020 | EGCG impedes human Tau aggregation and interacts with Tau | Shweta Kishor Sonawane | PMC7387440 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7387440/ | 0 |
| 2020 | Epigallocatechin-3-gallate inhibits self-renewal ability of lung cancer stem-like cells through inhibition of CLOCK | Pan Jiang | PMC7595654 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7595654/ | 0 |
| 2020 | Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer | Saleh A. Almatroodi | — | https://www.mdpi.com/1420-3049/25/14/3146 | 0 |
| 2020 | Epigallocatechin-3-Gallate-Loaded Gold Nanoparticles: Preparation and Evaluation of Anticancer Efficacy in Ehrlich Tumor-Bearing Mice | Mohamed A Safwat | PMC7559993 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7559993/ | 0 |
| 2020 | Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes | Xiaoqing Chi | PMC7790551 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7790551/ | 0 |
| 2020 | Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway | Bing-Huei Chen | — | https://www.nature.com/articles/s41598-020-62136-2 | 0 |
| 2020 | The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas | Shuangshuang Zhang | PMC7504867 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7504867/ | 0 |
| 2020 | Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking | Zarith Nameyrra | — | https://www.researchgate.net/publication/340088640_Iron_Chelation_Properties_of_Green_Tea_Epigallocatechin-3-Gallate_EGCG_in_Colorectal_Cancer_Cells_Analysis_on_TfrFth_Regulations_and_Molecular_Docking | 0 |
| 2020 | The Epigenetic Modification of Epigallocatechin Gallate (EGCG) on Cancer | Linqi Yang | — | https://www.researchgate.net/publication/341133182_The_Epigenetic_Modification_of_Epigallocatechin_Gallate_EGCG_on_Cancer | 0 |
| 2020 | Epigallocatechin-3-gallate downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8 harboring primary effusion lymphoma cells | Ling-Chun Yeh | — | https://www.sciencedirect.com/science/article/abs/pii/S0887233319306241 | 0 |
| 2020 | The Role of EGCG in Breast Cancer Prevention and Therapy | Adriana Romano | — | https://www.researchgate.net/publication/347873100_The_Role_of_EGCG_in_Breast_Cancer_Prevention_and_Therapy | 0 |
| 2019 | Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α | Zarith Nameyrra Md Nesran | PMC6942794 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6942794/ | 0 |
| 2019 | Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways | Tingting Li | PMC6650192 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6650192/ | 0 |
| 2019 | Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts | Ran Wei | PMC6826788 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6826788/ | 0 |
| 2019 | Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis | Hye Eun Lee | PMC6600669 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6600669/ | 0 |
| 2019 | Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine | Ran Wei | — | https://www.researchgate.net/publication/335091666_Epigallocatechin-3-Gallate_EGCG_Suppresses_Pancreatic_Cancer_Cell_Growth_Invasion_and_Migration_partly_through_the_Inhibition_of_Akt_Pathway_and_Epithelial-Mesenchymal_Transition_Enhanced_Efficacy_whe | 0 |
| 2019 | Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2 α /ATF4 and IRE1 α | Zarith Nameyrra Md Nesra | — | https://www.researchgate.net/publication/338109917_Induction_of_Endoplasmic_Reticulum_Stress_Pathway_by_Green_Tea_Epigallocatechin-3-Gallate_EGCG_in_Colorectal_Cancer_Cells_Activation_of_PERKp-eIF2_a_ATF4_and_IRE1_a | 0 |
| 2019 | EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells | Suchisnigdha | — | https://www.sciencedirect.com/science/article/abs/pii/S1756464619304773 | 0 |
| 2018 | Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy | Tumenjin Enkhbat | 30396944 | https://pubmed.ncbi.nlm.nih.gov/30396944/ | 0 |
| 2018 | (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress | Simona Martinotti | 29744892 | https://pubmed.ncbi.nlm.nih.gov/29744892/ | 0 |
| 2018 | Anti-fibrosis activity of combination therapy with epigallocatechin gallate, taurine and genistein by regulating glycolysis, gluconeogenesis, and ribosomal and lysosomal signaling pathways in HSC-T6 cells | Yan Li | PMC6257822 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6257822/ | 0 |
| 2018 | EGCG inhibits CSC-like properties through targeting miR-485/CD44 axis in A549-cisplatin resistant cells | Pan Jiang | 30182373 | https://pubmed.ncbi.nlm.nih.gov/30182373/ | 0 |
| 2018 | Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea | Islam Rady | — | https://www.researchgate.net/publication/321911600_Cancer_preventive_and_therapeutic_effects_of_EGCG_the_major_polyphenol_in_green_tea | 0 |
| 2018 | Interaction of poly-l-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells | Wei Xiong Siow | — | https://www.researchgate.net/publication/323871065_Interaction_of_poly-l-lysine_coating_and_heparan_sulfate_proteoglycan_on_magnetic_nanoparticle_uptake_by_tumor_cells | 0 |
| 2018 | (−)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway | Sha Feng | PMC5920970 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5920970/ | 0 |
| 2018 | Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway | Yongnan Li | 29446047 | https://pubmed.ncbi.nlm.nih.gov/29446047/ | 0 |
| 2018 | Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods Matter | Gregory Haskin | PMC6380985 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6380985/ | 0 |
| 2018 | Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer | Aide Negri | PMC6315581 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6315581/ | 0 |
| 2018 | Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells | Hirota Fujiki | PMC5824026 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5824026/ | 0 |
| 2018 | Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models | Ran Wei | — | https://www.researchgate.net/publication/328236054_Suppressing_glucose_metabolism_with_epigallocatechin-3-gallate_EGCG_reduces_breast_cancer_cell_growth_in_preclinical_models | 0 |
| 2018 | Suppressive Effects of EGCG on Cervical Cancer | Ying-Qi Wang | — | https://www.researchgate.net/publication/327610816_Suppressive_Effects_of_EGCG_on_Cervical_Cancer | 0 |
| 2018 | Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways | Gloria Bonuccelli | PMC6128439 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6128439/ | 0 |
| 2018 | The Effect of Ultrasound, Oxygen and Sunlight on the Stability of (−)-Epigallocatechin Gallate | Jiajun Zeng | PMC6225204 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6225204/ | 0 |
| 2018 | Nano-chemotherapeutic efficacy of (−) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling | Bakthavatchalam Velavan | — | https://www.sciencedirect.com/science/article/abs/pii/S0006291X18316073 | 0 |
| 2018 | Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth | Anchalee Rawangkan | PMC6222340 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6222340/ | 0 |
| 2017 | Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment | Hyung Joon Joo | PMC5943656 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5943656/ | 0 |
| 2017 | Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke | Qian Bai | — | https://www.sciencedirect.com/science/article/abs/pii/S0166432816307872 | 0 |
| 2017 | Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity | Juanjuan Wang | PMC5502302 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5502302/ | 0 |
| 2017 | (-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer's disease | Yufang Guo | 28520620 | https://pubmed.ncbi.nlm.nih.gov/28520620/ | 0 |
| 2017 | A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells | Lin Zhao | — | https://www.nature.com/articles/cddis2017563 | 0 |
| 2017 | Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate | Hirota Fujiki | PMC5693978 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5693978/ | 0 |
| 2017 | (−)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway | Yue Chen | PMC5490551 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5490551/ | 0 |
| 2017 | Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains | Feng Ye | PMC5473239 | https://pmc.ncbi.nlm.nih.gov/articles/PMC5473239/ | 0 |
| 2017 | Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration | Bose Karthikeyan | 27778132 | https://pubmed.ncbi.nlm.nih.gov/27778132/ | 0 |
| 2017 | EGCG, a tea polyphenol, as a potential mitigator of hematopoietic radiation injury in mice | Mrinalini Tiwari | — | https://www.sciencedirect.com/science/article/abs/pii/S0753332216326695 | 0 |
| 2017 | Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1 | Weixia Sun | 28457936 | https://pubmed.ncbi.nlm.nih.gov/28457936/ | 0 |
| 2017 | Comparative efficacy of epigallocatechin-3-gallate against H2O2-induced ROS in cervical cancer biopsies and HeLa cell lines | Sohail Hussain | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC5701581/ | 0 |
| 2016 | Protective effect of epigallocatechin-3-gallate (EGCG) via Nrf2 pathway against oxalate-induced epithelial mesenchymal transition (EMT) of renal tubular cells | Rattiyaporn Kanlaya | — | https://www.nature.com/articles/srep30233 | 0 |
| 2016 | Epigallocatechin gallate and mitochondria—A story of life and death | Marcos Roberto de Oliveira | — | https://www.sciencedirect.com/science/article/abs/pii/S1043661815301560 | 0 |
| 2016 | Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice | Subhayan Sur | 27058323 | https://pubmed.ncbi.nlm.nih.gov/27058323/ | 0 |
| 2016 | Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy | Piwen Wang | — | https://www.researchgate.net/publication/301933430_Green_tea_and_quercetin_sensitize_PC-3_xenograft_prostate_tumors_to_docetaxel_chemotherapy | 0 |
| 2016 | EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9 | Ke-Wang Luo | — | https://www.researchgate.net/publication/311782892_EGCG_inhibited_bladder_cancer_SW780_cell_proliferation_and_migration_both_in_vitro_and_in_vivo_via_down_regulation_of_NF-kB_and_MMP-9 | 0 |
| 2016 | In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity | Sainan Li | PMC4923908 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4923908/ | 0 |
| 2016 | Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer | Shusuke Toden | — | https://www.researchgate.net/publication/304940512_Epigallocatechin-3-gallate_targets_cancer_stem-like_cells_and_enhances_5-fluorouracil_chemosensitivity_in_colorectal_cancer | 0 |
| 2016 | Anti-cancer effect of EGCG and its mechanisms | Motofumi Kumazoe | — | https://www.researchgate.net/publication/318469094_Anti-cancer_effect_of_EGCG_and_its_mechanisms | 0 |
| 2015 | Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals | Chuan LI | — | https://www.researchgate.net/publication/282316276_Biocompatible_and_biodegradable_nanoparticles_for_enhancement_of_anti-cancer_activities_of_phytochemicals | 0 |
| 2015 | (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells | Munawwar Ali Khan | 25682960 | https://pubmed.ncbi.nlm.nih.gov/25682960/ | 0 |
| 2015 | Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury | Pere Boadas-Vaello | PMC4625495 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4625495/ | 0 |
| 2015 | Estrogen receptor-α36 is involved in epigallocatechin-3-gallate induced growth inhibition of ER-negative breast cancer stem/progenitor cells | Xiaohua Pan | — | https://www.researchgate.net/publication/289992020_Estrogen_receptor-a36_is_involved_in_epigallocatechin-3-gallate_induced_growth_inhibition_of_ER-negative_breast_cancer_stemprogenitor_cells | 0 |
| 2015 | Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells | Qing-Yi Lu | PMC4523095 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4523095/ | 0 |
| 2015 | Food Inhibits the Oral Bioavailability of the Major Green Tea Antioxidant Epigallocatechin Gallate in Humans | Nenad Naumovski | — | https://www.mdpi.com/2076-3921/4/2/373 | 0 |
| 2015 | Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate | Sabita N Saldanha | PMC4043227 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4043227/ | 0 |
| 2015 | (−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression | Xiang Chang | — | https://www.sciencedirect.com/science/article/abs/pii/S0014482715001366 | 0 |
| 2015 | Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2‑mediated glycolysis | Feng Gao | 25591943 | https://pubmed.ncbi.nlm.nih.gov/25591943/ | 0 |
| 2015 | A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea | Dawn Lemanne, Keith I. Block | — | https://pmc.ncbi.nlm.nih.gov/articles/PMC4739749/pdf/cureus-0007-000000000441.pdf | 0 |
| 2015 | A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea | Dawn Lemanne | — | https://glennsabin.com/wp-content/uploads/2016/01/Glenn_Sabin_Cureus_case_report.pdf | 0 |
| 2015 | (-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression | Xiang Chang | 25882496 | https://pubmed.ncbi.nlm.nih.gov/25882496/ | 0 |
| 2014 | Phase 2 Trial of Daily, Oral Polyphenon E in Patients with Asymptomatic, Rai Stage 0-II Chronic Lymphocytic Leukemia(CLL) | Tait D Shanafelt | PMC3902473 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3902473/ | 0 |
| 2014 | Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications | Brahma N Singh | PMC4082721 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4082721/ | 0 |
| 2014 | Augmented cellular uptake of nanoparticles using tea catechins: effect of surface modification on nanoparticle-cell interaction | Yi-Ching Lu | 25069428 | https://pubmed.ncbi.nlm.nih.gov/25069428/ | 0 |
| 2014 | New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate | Hae-Suk Kim | PMC3909779 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3909779/ | 0 |
| 2014 | Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide | Usha Gundimeda | 24508265 | https://pubmed.ncbi.nlm.nih.gov/24508265/ | 0 |
| 2014 | Green Tea Polyphenol Epigallocatechin 3-Gallate, Contributes to the Degradation of DNMT3A and HDAC3 in HCT 116 Human Colon Cancer Cells | VONDINA R MOSELEY | PMC4017340 | https://pmc.ncbi.nlm.nih.gov/articles/PMC4017340/ | 0 |
| 2014 | Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84 | Claudia Hanau | PMC3901999 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3901999/ | 0 |
| 2013 | Epigallocatechin-3-gallate-capped Ag nanoparticles: preparation and characterization | Shokit Hussain | — | https://link.springer.com/article/10.1007/s00449-013-1094-0 | 0 |
| 2013 | Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy | Inyoung Kim | — | https://www.researchgate.net/publication/250926581_Targeting_the_AMP-Activated_Protein_Kinase_for_Cancer_Prevention_and_Therapy | 0 |
| 2013 | Bioactivity-Guided Identification and Cell Signaling Technology to Delineate the Lactate Dehydrogenase A Inhibition Effects of Spatholobus suberectus on Breast Cancer | Zhiyu Wang | PMC3572989 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3572989/ | 0 |
| 2013 | EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression | Jian-Wei Gu | PMC3649947 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3649947/ | 0 |
| 2013 | Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells | Di Chen | PMC3334407 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3334407/ | 0 |
| 2013 | (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation | Murli Manohar | 22959059 | https://pubmed.ncbi.nlm.nih.gov/22959059/ | 0 |
| 2013 | Antioxidant effects of green tea | SARAH C FORESTER | PMC3679539 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3679539/ | 0 |
| 2013 | Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics | Su-Ni Tang | PMC3480310 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3480310/ | 0 |
| 2012 | Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells | Piwen Wang | — | https://www.tandfonline.com/doi/abs/10.1080/01635581.2012.661514 | 0 |
| 2012 | Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea | Guang-Jian Du | PMC3509513 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3509513/ | 0 |
| 2012 | Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines | Chien-Hung Lin | PMC3575296 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3575296/ | 0 |
| 2012 | Prevention effect of EGCG in rat's lung cancer induced by benzopyrene | Q.-X. Feng | — | https://www.researchgate.net/publication/287947721_Prevention_effect_of_EGCG_in_rat's_lung_cancer_induced_by_benzopyrene | 0 |
| 2011 | Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol | Lian-Ying Wu | — | https://www.sciencedirect.com/science/article/abs/pii/S0304416511000936 | 0 |
| 2011 | Green tea constituents (−)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I– and topoisomerase II–DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide | Miguel López-Lázaro | — | https://academic.oup.com/mutage/article-abstract/26/4/489/1189168?redirectedFrom=fulltext&login=false | 0 |
| 2010 | Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer | Imtiaz A Siddiqui | — | https://www.researchgate.net/publication/49701530_Green_tea_polyphenol_EGCG_blunts_androgen_receptor_function_in_prostate_cancer | 0 |
| 2010 | The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention | Joshua D Lambert | PMC2946098 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2946098/ | 0 |
| 2010 | (−)-Epigallocatechin Gallate, A Major Constituent of Green Tea, Poisons Human Type II Topoisomerases | Omari J Bandele | PMC2893035 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2893035/ | 0 |
| 2010 | Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate | Huihui Zhang | 20951799 | https://pubmed.ncbi.nlm.nih.gov/20951799/ | 0 |
| 2010 | Epigenetic targets of bioactive dietary components for cancer prevention and therapy | Syed M Meeran | PMC3024548 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3024548/ | 0 |
| 2010 | (-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells | Guo-Qing Tang | 20127255 | https://pubmed.ncbi.nlm.nih.gov/20127255/ | 0 |
| 2010 | Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells | Thomas De Luca | — | https://www.researchgate.net/publication/44644721_Reciprocal_Relationship_Between_Cytosolic_NADH_and_ENOX2_Inhibition_Triggers_Sphingolipid-Induced_Apoptosis_in_HeLa_Cells | 0 |
| 2009 | Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin | Hsieh, T.-C | PMC3641843 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3641843/ | 0 |
| 2008 | Dual Roles of Nrf2 in Cancer | Alexandria Lau | PMC2652397 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2652397/ | 0 |
| 2008 | Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells | Anindita Agarwal | 21479441 | https://pubmed.ncbi.nlm.nih.gov/21479441/ | 0 |
| 2007 | Epigallocatechin-3-gallate inhibits secretion of TNF-alpha, IL-6 and IL-8 through the attenuation of ERK and NF-kappaB in HMC-1 cells | Hye-Young Shin | 17135765 | https://pubmed.ncbi.nlm.nih.gov/17135765/ | 0 |
| 2006 | Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase | Changhong Li | 16476731 | https://pubmed.ncbi.nlm.nih.gov/16476731/ | 0 |
| 2005 | Epigallocatechin-3-gallate, a green-tea polyphenol, suppresses Rho signaling in TWNT-4 human hepatic stellate cells | Nobuhiko Higashi | 15976760 | https://pubmed.ncbi.nlm.nih.gov/15976760/ | 0 |
| 2005 | EGCG upregulates phase-2 detoxifying and antioxidant enzymes via the Nrf2 signaling pathway in human breast epithelial cells | Hye-Kyung Na | — | https://aacrjournals.org/cancerres/article/65/9_Supplement/367/519963/EGCG-upregulates-phase-2-detoxifying-and | 0 |
| 2004 | Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice | Joshua D Lambert | 15284381 | https://pubmed.ncbi.nlm.nih.gov/15284381/ | 0 |
| 2003 | Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists | Renzo Deana | 12719785 | https://pubmed.ncbi.nlm.nih.gov/12719785/ | 0 |
| 2002 | Cellular thiol status-dependent inhibition of tumor cell growth via modulation of retinoblastoma protein phosphorylation by (-)-epigallocatechin | David Opare Kennedy | 11880178 | https://pubmed.ncbi.nlm.nih.gov/11880178/ | 0 |
| 2002 | Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations | Wan-Mohaiza Dashwood | 12176021 | https://pubmed.ncbi.nlm.nih.gov/12176021/ | 0 |
| 2000 | Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture | D. James Morre´ | — | — | 0 |
| 2000 | Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells | Fengge Ren | — | https://www.nature.com/articles/1203511 | 0 |
| 2022 | Targeting cancer stem cells by nutraceuticals for cancer therapy | Man Chu | — | https://www.sciencedirect.com/science/article/abs/pii/S1044579X21002029 | 0 |
| 2010 | Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer | Anna Slusarz | 20395211 | https://pubmed.ncbi.nlm.nih.gov/20395211/ | 0 |
| 2012 | Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines | Simona Dinicola | PMC3269711 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3269711/ | 0 |
| 2013 | Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action | Husain Yar Khan | 24123728 | https://pubmed.ncbi.nlm.nih.gov/24123728/ | 0 |
| 2020 | Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer | Susanne M. Henning | — | https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00565g | 0 |
| 2013 | Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea | Piwen Wang | PMC3858726 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3858726/ | 0 |
| 2010 | The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition | Su-Ni Tang | — | https://link.springer.com/article/10.1186/1750-2187-5-14 | 0 |
| 2010 | The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition | Su-Ni Tang | PMC2933702 | https://pmc.ncbi.nlm.nih.gov/articles/PMC2933702/ | 0 |
| 2025 | Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol | Mohamed Ahmed | PMC12225039 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12225039/ | 0 |
| 2022 | A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease | Sudhir Kshirsagar | PMC9454743 | https://pmc.ncbi.nlm.nih.gov/articles/PMC9454743/ | 0 |