tbResList Print — EDM Evodiamine

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Product

EDM Evodiamine
Description: <b>Evodiamine</b> is a bioactive alkaloid isolated primarily from the fruit of the traditional Chinese medicinal herb Evodia rutaecarpa.
<b><a href="https://www.sciencedirect.com/science/article/abs/pii/S0378874120330464">Evodiamine</b> is a natural alkaloid from Evodia rutaecarpa, a traditional Chinese medicine. It has various pharmacological activities, such as anti-inflammatory, anti-cancer, anti-microbial and metabolic regulation, but also shows hepatotoxicity and cardiotoxicity.</a> <br>

Pathway results for Effect on Cancer / Diseased Cells

Mitochondria & Bioenergetics ⓘ

Bfl-1↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   cFLIP↓, 1,   IAP1↓, 1,   IAP2↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   TumCG↓, 1,  

Migration ⓘ

MMP9↓, 1,   MUC1-C↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 1,   NF-kB↓, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

MDR1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2022Evodiamine exerts inhibitory roles in non‑small cell lung cancer cell A549 and its sub‑population of stem‑like cellsXiumin LuPMC9748704https://pmc.ncbi.nlm.nih.gov/articles/PMC9748704/0
2020Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axisZe-Bo JiangPMC7677782https://pmc.ncbi.nlm.nih.gov/articles/PMC7677782/0
2005Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasionYasunari Takada15710601https://pubmed.ncbi.nlm.nih.gov/15710601/0