tbResList Print — Ger Germacranolide

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Product

Ger Germacranolide
Description: <b>A germacranolide sesquiterpene lactone (GSL)</b> was isolated from Siegesbeckia glabrescens<br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   Shh↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PD-1↓, 1,   PD-L1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2016A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cellsHwa Jin LeePMC5038360https://pmc.ncbi.nlm.nih.gov/articles/PMC5038360/0
2023Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axisHuan LiuPMC10770033https://pmc.ncbi.nlm.nih.gov/articles/PMC10770033/0