tbResList Print — Ger Germacranolide

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Product

Ger Germacranolide
Description: <b>A germacranolide sesquiterpene lactone (GSL)</b> was isolated from Siegesbeckia glabrescens<br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   Shh↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PD-1↓, 1,   PD-L1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSR↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT∅, 1,   NADPH↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

ALAT∅, 1,   AST∅, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 13

Research papers

Year Title Authors PMID Link Flag
2018Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing EnzymesBarbara PavanPMC5788896https://pmc.ncbi.nlm.nih.gov/articles/PMC5788896/0
2016A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cellsHwa Jin LeePMC5038360https://pmc.ncbi.nlm.nih.gov/articles/PMC5038360/0
2023Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axisHuan LiuPMC10770033https://pmc.ncbi.nlm.nih.gov/articles/PMC10770033/0