LRP6 (Low-density lipoprotein receptor–related protein 6) is a single-pass transmembrane co-receptor that plays an essential role in the canonical Wnt/β-catenin signaling pathway. Wnt signaling is critically involved in embryonic development, cell proliferation, differentiation, and tissue homeostasis. Dysregulation of this pathway is a well-known contributor to oncogenesis.
LRP6 plays a significant role in the regulation of the Wnt/β-catenin signaling pathway—a key driver in many cancers. Its overexpression is commonly observed in various tumor types and often correlates with an aggressive clinical profile, including poor survival outcomes. These findings not only underscore the importance of LRP6 as a prognostic biomarker but also highlight its potential as a target for novel therapeutic interventions.
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