MKI67 is the gene that encodes the Ki-67 protein, a well-established marker of cellular proliferation. Ki-67 is expressed during all active phases of the cell cycle (G1, S, G2, and mitosis) but is absent in resting (G0) cells. Because of its tight correlation with cell proliferation, Ki-67 is widely used in clinical and research settings to assess the growth fraction of a given cell population, particularly in cancer.
Tumors with high proliferative activity almost invariably show elevated levels of Ki-67. This increased expression is reflective of rapid cell division and active tumor growth.
High Ki-67 levels are frequently associated with more aggressive tumor behavior, increased likelihood of recurrence, and poorer overall survival in many cancer types.
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