Cofilin is an actin-binding protein that plays a central role in regulating actin dynamics and cytoskeletal remodeling. Its activity is essential for various cellular functions, including migration, invasion, and cell division.
High levels of active cofilin have been associated with increased invasiveness and metastatic potential in several tumor types, often correlating with a poorer prognosis.
Assessing cofilin activity (for example, via levels of phosphorylated vs. non-phosphorylated protein) might provide insights into the metastatic potential of a tumor.
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