ERK5 (extracellular signal-regulated kinase 5, also known as MAPK7)
ERK5 is part of the MAP kinase family and plays roles in cell proliferation, differentiation, survival, and angiogenesis. Its activation can be triggered by growth factors and various stress signals.
Elevated ERK5 activity is generally associated with:
-Enhanced tumor cell proliferation
-Increased metastatic potential
-Shorter survival times and poor prognosis in various cancers (particularly breast, lung, and prostate cancers)
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