AEG-1 (Astrocyte Elevated Gene-1), also known as Metadherin (MTDH) or LYRIC, is an oncogene that has garnered considerable attention due to its multifaceted roles in tumor progression, metastasis, and chemoresistance.
AEG-1 is involved in several cellular processes including proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition (EMT).
It influences multiple signaling pathways such as PI3K/AKT, NF-κB, and Wnt/β-catenin, which are critical for promoting survival, proliferation, and metastatic potential.
AEG-1’s ability to interact with various proteins and pathways makes it a central hub in fostering a supportive environment for tumor growth and progression.
AEG-1 is overexpressed in a wide range of cancers including breast, prostate, liver (hepatocellular carcinoma), glioblastoma, melanoma, and colorectal cancers, among others.
High expression levels are frequently detected in advanced tumor stages and often correlate with aggressive tumor phenotypes.
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