BOK (Bcl-2-related ovarian killer) is a member of the Bcl-2 family of proteins and is generally considered a pro-apoptotic factor.
BOK is categorized as a pro-apoptotic protein and is thought to contribute to the intrinsic (mitochondrial) pathway of apoptosis.
Although direct targeting of BOK is not yet well established, restoring or enhancing its expression in tumors with low BOK levels could be a strategy to re-sensitize cancer cells to apoptosis.
Alterations in BOK expression have been observed in several types of cancers. In some tumor models, downregulation or loss of BOK expression may be associated with reduced apoptotic response, which can contribute to uncontrolled cell survival.
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