EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as CD147 or basigin
EMMPRIN is a transmembrane glycoprotein that facilitates intercellular communication.
It is best known for its role in upregulating matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix (ECM). This degradation is a key step in tumor invasion and metastasis.
EMMPRIN is overexpressed in a wide range of cancers, including breast, head and neck, lung, liver, and colorectal cancers, among others.
Increased EMMPRIN expression is often observed in more aggressive tumor types and is correlated with enhanced invasive capabilities.
High EMMPRIN levels are detected not only in tumor cells but also in the surrounding stromal cells, supporting a pro-tumorigenic microenvironment.
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