HDAC3 is an enzyme belonging to the class I histone deacetylases and plays a key role in transcriptional regulation by removing acetyl groups from histone tails.
This deacetylase activity leads to chromatin condensation and generally results in transcriptional repression.
HDAC3 is involved in multiple cellular processes, including cell cycle regulation, apoptosis, and differentiation.
HDAC3 is frequently found to be overexpressed in several cancer types, including breast, colorectal, liver, lung, and hematological malignancies.
Elevated HDAC3 levels have been associated with the repression of tumor suppressor genes and deregulation of proliferative pathways.
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