Interstitial markers are proteins expressed primarily by components of the tumor stroma (the supportive and reactive tissue surrounding tumor cells).
They are often used to identify fibroblasts, myofibroblasts, and other stromal cells actively participating in the tumor microenvironment.
Common interstitial markers include vimentin, α-smooth muscle actin (α-SMA), fibroblast activation protein (FAP), and platelet-derived growth factor receptor beta (PDGFR-β).
Interstitial markers, expressed by the tumor stroma (including proteins such as vimentin, α-SMA, FAP, and PDGFR-β), play important roles in defining the tumor microenvironment. Their increased expression often correlates with a reactive stroma that promotes tumor invasion, metastasis, and therapeutic resistance.
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