cPLA2 is a key enzyme that hydrolyzes membrane phospholipids to release arachidonic acid, serving as the precursor for the synthesis of eicosanoids (prostaglandins, leukotrienes, etc.). These lipid mediators can significantly influence inflammation, cell proliferation, survival, angiogenesis, and metastasis—all processes that are critical in cancer development and progression.
cPLA2 plays a multifaceted role in carcinogenesis through its involvement in the production of bioactive lipids that regulate inflammation, cell growth, and metastasis. Its expression is frequently elevated in several cancers—including breast, prostate, colorectal, lung, ovarian, and head and neck cancers—and is generally associated with a poorer prognosis.
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