Th17 cells are a distinct subset of CD4+ T helper cells characterized by their production of interleukin-17 (IL-17) family cytokines (most notably IL-17A and IL-17F), as well as other effector molecules like IL-21 and IL-22. These cells play a key role in mediating inflammatory responses and defending against extracellular pathogens, particularly fungi and bacteria.
Th17 cells have been reported to exhibit both pro-tumor and anti-tumor properties:
– Anti-Tumor Effects: In some contexts, the pro-inflammatory cytokines produced by Th17 cells can enhance anti-tumor immunity by recruiting and activating other immune cells (e.g., cytotoxic T lymphocytes and natural killer cells).
– Pro-Tumor Effects: Conversely, chronic inflammation driven by Th17 cells may promote tumor progression by encouraging angiogenesis, suppressing effective anti-tumor immune responses, or by directly supporting tumor cell survival and metastasis.
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