Breast Tumor Kinase (BrK), also known as Protein Tyrosine Kinase 6 (PTK6).
BrK is involved in intracellular signaling, influencing pathways related to cell proliferation, migration, and differentiation.
– In normal tissues, its expression is often limited; however, aberrant expression in tumors may contribute to oncogenic processes, including enhanced cell survival and metastatic potential.
– The kinase modulates key signaling cascades such as PI3K/AKT and MAPK that drive tumor progression.
BrK is most widely studied in breast cancer where it is frequently overexpressed, especially in a subset of tumors that do not express classical receptors (e.g., triple-negative breast cancers) as well as in some hormone receptor–positive cases.
High BrK expression has been linked in several studies to enhanced tumor progression, increased metastasis, and a poorer overall survival.
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