CCL20 (Chemokine [C-C motif] ligand 20), also known as MIP-3α, plays a role in immune cell recruitment and inflammation.
Upregulation in Tumors:
– Many studies have noted elevated levels of CCL20 in tumor tissues compared to adjacent normal tissues in various cancers such as colorectal, hepatocellular, breast, and pancreatic cancers.
– Increased CCL20 expression is often associated with an inflammatory tumor microenvironment that promotes tumor cell migration and invasion.
Elevated CCL20 levels have been correlated with enhanced tumor invasiveness and metastasis in several cancer types, likely driven by its ability to modulate the local immune response and promote a pro-tumorigenic microenvironment.
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