OATs (Organic Anion Transporters) are a family of membrane transport proteins primarily involved in the uptake and disposition of organic anions, including drug metabolites, toxins, and endogenous compounds. They belong mainly to the SLC22 gene family.
OATs are expressed in a variety of tissues—with high expression in the kidney, liver, and to some extent in the intestine and brain.
• In cancers, the expression of OATs can be altered (either downregulated or, in some contexts, upregulated) relative to the corresponding normal tissue.
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