DJ-1 (also known as PARK7)
Elevated levels of DJ-1 have been observed in tumors and are often correlated with more advanced disease stages. Overexpression of DJ-1 may contribute to cell proliferation and invasion, leading to an overall poorer prognosis.
– DJ-1 functions as an oxidative stress sensor. Under conditions of increased ROS, DJ-1 undergoes specific oxidative modifications that can alter its structure and function. This allows DJ-1 to participate in protective responses against ROS-induced cellular damage. DJ-1 indirectly reduces the generation of excessive ROS and the resulting oxidative damage.
-In the context of cancer, increased DJ-1 expression can help tumor cells evade the detrimental effects of ROS, contributing to resistance against oxidative stress–inducing therapies.
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