Estrogen receptor (ER) signaling plays a crucial role in various physiological processes, including the regulation of the menstrual cycle, reproductive functions, and bone health.
There are two main types of estrogen receptors:
ERα (Estrogen Receptor Alpha): Primarily found in breast tissue, it is the most studied receptor in relation to breast cancer.
ERβ (Estrogen Receptor Beta): Found in various tissues, including the ovaries, prostate, and brain, its role in cancer is less well understood.
Approximately 70% of breast cancers are ER-positive, meaning they grow in response to estrogen.
ER signaling promotes cell proliferation and survival, contributing to tumor growth.
(Will delete Record if Target field = "Delete") Home