Mortalin (mtHsp70/HSPA9) is a chaperone protein primarily involved in mitochondrial protein import and folding.
– Mortalin's interaction with p53 is a well-studied mechanism in cancer. By binding to and inactivating p53, Mortalin can prevent apoptosis and allow the survival of damaged or transformed cells.
– Overexpression of Mortalin has been observed in various cancers, including breast, colon, liver, and neuroblastoma, among others.
– Its elevated levels can support tumor cell proliferation, survival, and resistance to physiologic stress and chemotherapy.
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