c‑MYB is a transcription factor that plays critical roles in cell proliferation, differentiation, and apoptosis.
– c‑MYB is a transcription factor essential for normal hematopoiesis and the regulation of genes involved in cell cycle progression, differentiation, and survival.
– Aberrant or sustained expression of c‑MYB is found in several malignancies, particularly hematological cancers such as acute leukemias, as well as solid tumors including breast and colon cancers.
– Overexpression or mutation of c‑MYB can lead to enhanced cell proliferation and impaired differentiation, creating an environment conducive to malignant transformation and tumor maintenance.
– In several studies, high levels of c‑MYB correlate with more aggressive tumor behavior and poorer clinical outcomes, such as reduced overall survival and an increased likelihood of relapse.
c‑MYB plays a pivotal role in the regulation of cell proliferation, differentiation, and survival. Its dysregulation in cancer contributes to unchecked growth and resistance to cell death, correlating with aggressive disease and poorer clinical outcomes.
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