Alix (ALG‑2–interacting protein X), also known as AIP‑1, is a multifunctional protein that interacts with actin and other components of the cytoskeleton.
– Altered expression or localization of Alix has been observed in various cancers, including breast, prostate, and colorectal cancers.
– Alix may contribute to tumor growth by affecting apoptosis and cell survival. In some contexts, it is suggested that Alix can modulate apoptotic signaling pathways.
– Studies have reported that Alix expression may be upregulated in certain tumor types, with changes in subcellular localization (e.g., increased cytoplasmic or membranous expression) linked to aggressive behavior.
– In some cancers, altered Alix levels have been associated with enhanced invasive and metastatic potential.
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