Set9, also known as SETD7 (SET domain containing lysine methyltransferase 7), is an enzyme that mediates the methylation of lysine residues on both histone and non-histone proteins.
SETD7 (Set9) is a lysine methyltransferase with complex roles in cancer, affecting both histone and non-histone proteins. Its expression can influence key pathways related to cell cycle control, apoptosis, and inflammation. The prognostic implications of SETD7 expression in cancers are nuanced—while in some instances it supports tumor-suppressive mechanisms (e.g., via p53 activation), in others it may promote tumor progression through alternative signaling pathways, such as those mediated by NF-κB.
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