Prx I is an endogenous protein—one of the six members of the peroxiredoxin family.
• It is naturally expressed in cells and plays a role in antioxidant defense by reducing hydrogen peroxide and organic hydroperoxides, thereby protecting cells against oxidative damage.
Prx I is overexpressed in a range of human cancers. Increased levels have been detected in tumors such as breast, lung, colorectal, liver, pancreatic, and head and neck cancers. In some cases, this upregulation is thought to be a response to the enhanced oxidative stress experienced by rapidly proliferating tumor cells.
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