Frataxin (has antioxidant properties) is a mitochondrial protein primarily known for its role in:
Iron–sulfur (Fe–S) cluster biogenesis.
Iron homeostasis.
Protection against oxidative stress.
Some studies have demonstrated that altered (often reduced) frataxin expression correlates with aggressive tumor features and poor patient outcomes. The rationale is that a decrease in frataxin might enhance oxidative damage and support a more aggressive phenotype.
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