Decorin is a small leucine‐rich proteoglycan found in the extracellular matrix that plays a multifaceted role in regulating cell growth, angiogenesis, and collagen fibrillogenesis. Its interaction with growth factors (such as transforming growth factor‐β [TGF‐β]), receptor tyrosine kinases, and other extracellular molecules contributes to its ability to influence tumor cell behavior. Numerous studies have investigated the expression of decorin in various cancers, revealing that its levels can influence prognosis.
Decorin is generally downregulated in the tumor microenvironment.
– Lower decorin levels have been correlated with desmoplasia and a more fibrotic, aggressive tumor phenotype, suggesting poorer prognosis.
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