Macrophage Inflammatory Protein‐1β (MIP-1β), also known as CCL4, is a chemokine involved in recruiting and activating various immune cells such as monocytes, T lymphocytes, and natural killer (NK) cells within the tumor microenvironment. Its expression levels can influence immune cell infiltration and contribute to shaping the antitumor immune response.
– MIP-1β can be secreted by tumor-associated macrophages and other immune cells
within the tumor microenvironment.
– Elevated levels are sometimes associated with improved immune surveillance.
• Dual Role: The role of MIP-1β in cancer is complex; while it promotes immune cell recruitment and may enhance antitumor immunity, in some conditions, chronic inflammation can facilitate tumor progression.
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