Histone deacetylase 8 (HDAC8) is one of the class I histone deacetylases involved in the removal of acetyl groups from histone and non-histone proteins. This deacetylation alters chromatin structure and gene expression and has been associated with various cellular processes including proliferation, apoptosis, and differentiation. Aberrant expression or activity of HDAC8 has been reported in several types of cancer where it can influence tumor behavior and prognosis.
– Studies report increased HDAC8 levels in certain aggressive tumor subtypes. – Overexpression is often correlated with higher tumor grade, increased cell proliferation, and poorer patient outcomes.
HDAC8 overexpression is frequently associated with a more aggressive disease course and poorer prognosis in several types of cancer, including breast cancer, neuroblastoma, AML, and colorectal cancer. Its role in deacetylation and chromatin remodeling makes it an attractive target for therapeutic intervention, and ongoing studies aim to clarify its full prognostic and predictive value in cancer management.
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