TFEB is a member of the MiT/TFE (microphthalmia/transcription factor E) family and plays a crucial role in controlling the transcription of genes related to lysosome function and autophagy.
• Its subcellular localization (cytosolic versus nuclear) is tightly regulated, with nuclear translocation being associated with transcriptional activation of target genes.
TFEB is emerging as an important regulator in cancer biology, and its role as a prognostic marker is under active research. Its expression and activation state may offer insights into tumor behavior, especially regarding autophagy and metabolic adaptation.
Overexpressed in RCC, Pca,
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