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tid		Target	CardioT	Cancers General Effect on Target

Name	Cardiotoxicity
Source
Type

Cardiotoxicity in the context of cancer generally refers to the potential harmful effects that cancer therapies can have on the heart. This is an important consideration because many effective cancer treatments can also damage cardiac tissue, leading to short-term or long-term cardiovascular complications. 
 
Mechanisms of Cardiotoxicity in Cancer Therapy 
-Chemotherapy Agents: 
     Anthracyclines (e.g., doxorubicin, epirubicin): 
     Alkylating Agents (e.g., cyclophosphamide): 
     Antimetabolites (e.g., 5-fluorouracil, capecitabine): 
-Targeted Therapies: 
    HER2 inhibitors (e.g., trastuzumab): 
    Tyrosine Kinase Inhibitors (e.g., sunitinib, imatinib): 
-Radiation Therapy: 
    Thoracic irradiation: 
 
Natural Products that may reduce Cardiotoxicity: 
-Resveratrol 
-Curcumin 
-EGCG 
-Quercetin 
-Garlic Extract (Allicin) 
-Omega-3 Fatty Acids: Fish oil (EPA and DHA), flaxseeds, chia seeds, walnuts. 
 
 
Natural products like resveratrol, curcumin, EGCG, quercetin, garlic extract, and omega-3 fatty acids show potential in reducing cardiotoxicity by targeting oxidative stress, inflammation, and apoptotic pathways.

Cardiotoxicity in the context of cancer generally refers to the potential harmful effects that cancer therapies can have on the heart. This is an important consideration because many effective cancer treatments can also damage cardiac tissue, leading to short-term or long-term cardiovascular complications.

Mechanisms of Cardiotoxicity in Cancer Therapy
-Chemotherapy Agents:
     Anthracyclines (e.g., doxorubicin, epirubicin):
     Alkylating Agents (e.g., cyclophosphamide):
     Antimetabolites (e.g., 5-fluorouracil, capecitabine):
-Targeted Therapies:
    HER2 inhibitors (e.g., trastuzumab):
    Tyrosine Kinase Inhibitors (e.g., sunitinib, imatinib):
-Radiation Therapy:
    Thoracic irradiation:

Natural Products that may reduce Cardiotoxicity:
-Resveratrol
-Curcumin
-EGCG
-Quercetin
-Garlic Extract (Allicin)
-Omega-3 Fatty Acids: Fish oil (EPA and DHA), flaxseeds, chia seeds, walnuts.

Natural products like resveratrol, curcumin, EGCG, quercetin, garlic extract, and omega-3 fatty acids show potential in reducing cardiotoxicity by targeting oxidative stress, inflammation, and apoptotic pathways.

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