BTG3 (B-cell translocation gene 3) is considered a tumor suppressor gene involved in cell cycle regulation, apoptosis, and differentiation.
-BTG3 belongs to the BTG/Tob family of anti-proliferative genes and plays a role in cell cycle regulation by inhibiting cell proliferation and promoting differentiation.
-Several studies have reported reduced expression or loss of BTG3 in different tumor types, including lung, breast, prostate, ovarian, and colorectal cancers.
-Low BTG3 levels have been correlated with higher tumor grade, increased metastasis, and advanced clinical stage.
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