The ratio between NADH and NAD⁺ is a key indicator of a cell’s metabolic state.
• In many cancers, changes in this ratio may indicate increased reliance on glycolysis or alterations in mitochondrial function.
• Some studies have suggested that abnormal NADH metabolism or shifts in the NADH/NAD⁺ ratio can be correlated with tumor aggressiveness or response to therapy.
• For example, in certain cancers, a higher NADH/NAD⁺ ratio may be associated with more aggressive behavior, resistance to apoptosis, or poor prognosis.
A shift toward a higher NADH/NAD⁺ ratio can potentially impair these regulatory pathways, diminishing the cell’s capacity to respond to or repair damage from elevated ROS levels.
-A high NADH/NAD⁺ ratio can lead to increased ROS production, particularly through mitochondrial electron leakage.
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