Paxillin is a multi-domain adaptor protein localized to focal adhesions that plays a critical role in integrin‐mediated signal transduction, cytoskeletal reorganization, and cellular motility.
Not only the overall expression levels, but also the phosphorylation state of paxillin (e.g., at tyrosine residues) is crucial. Abnormal phosphorylation can alter its interactions and downstream signaling, further enhancing cancer cell motility and survival.
Paxillin is frequently upregulated or aberrantly activated in various cancers. High expression and/or abnormal phosphorylation status of paxillin tends to correlate with increased tumor aggressiveness, enhanced metastatic potential, and generally poorer prognosis.
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