HDAC10 (a member of the histone deacetylase family)
• HDAC10 is involved in chromatin remodeling, gene expression, DNA repair, and autophagy.
• Its activity may influence tumor cell survival, invasiveness, and resistance to therapy through regulation of these pathways.
HDAC10 appears to play a context-dependent role in various cancers. In several studies—particularly in ovarian and lung cancers—elevated HDAC10 expression has been associated with poorer clinical outcomes, including chemoresistance and increased tumor aggressiveness.
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