Also known as FBW7.
FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor.
FBW7 mutations or loss of function have been observed in solid tumors such as colorectal cancer, breast cancer, and pancreatic cancer. The loss of FBW7 activity can lead to the accumulation of oncogenic proteins like c-Myc, Notch, and cyclin E, which drive tumorigenesis.
FBW7 mutations have been associated with several types of cancer, reinforcing its classification as a tumor suppressor gene.
FBXW7 is a critical regulator of protein degradation and plays a significant role in the progression and prognosis of various cancers. Its often downreguled or mutated and is often associated with poor prognosis, increased tumor aggressiveness, and resistance to therapies.
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