p90RSK (90 kDa Ribosomal S6 Kinase)
p90RSK is a serine/threonine kinase and a downstream effector of the MAPK/ERK signaling pathway. It plays a critical role in regulating cellular processes such as proliferation, survival, migration, and protein synthesis, all of which can contribute to tumor development and progression.
– p90RSK is activated in response to mitogenic stimuli through the MAPK/ERK pathway.
– Once activated, it phosphorylates a variety of substrates that promote cell cycle progression and proliferation.
– Aberrant activation of p90RSK may lead to uncontrolled cell division, a hallmark of cancer.
– Several studies have reported that elevated p90RSK activity or expression is found in various tumor types, including breast, lung, and prostate cancers.
– High levels of activated p90RSK are often associated with aggressive tumor behavior, enhanced proliferation, and metastatic potential.
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