Insulin-like Growth Factor Binding Protein 7 (IGFBP7) is a secreted protein that modulates the actions of insulin-like growth factors (IGFs) and has been implicated in tumorigenesis, angiogenesis, cellular senescence, and apoptosis.
- Reduced expression of IGFBP7 has been associated with tumor progression, whereas in some settings, increased IGFBP7 levels may correlate with an adverse tumor microenvironment or resistance to apoptosis.
- In cancers such as colorectal and thyroid cancer, low IGFBP7 expression has been linked to poorer survival rates and more aggressive disease, supporting a tumor-suppressive role.
Overall, many studies tend to view IGFBP7 as a marker of better prognosis when expressed at normal or high levels, particularly in cases where it enforces cell cycle arrest or senescence.
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