MAD refers to a group of proteins that are primarily known as antagonists of MYC function. They are often categorized as members of the MAD/MXD family of transcriptional repressors, which include MAD1, MAD2 (not to be confused with the spindle assembly checkpoint protein MAD2, which is distinct), MAD3, MAD4, and related factors. These proteins generally oppose MYC activity by forming complexes that repress transcription at MYC target genes, thereby inhibiting cell proliferation and promoting differentiation.
Downregulation or loss of MAD expression is often associated with poor prognosis. This is because diminished MAD activity results in enhanced MYC function, promoting aggressive tumor behavior, rapid proliferation, and often treatment resistance.
-MAD protein, a late marker of oxidative stress and cell injury.
(Will delete Record if Target field = "Delete") Home