Immunoglobulins, particularly IgG and IgM, are traditionally recognized as components of the adaptive immune response; however, they have also been observed to be expressed by certain tumor cells or to play roles in the tumor microenvironment.
Immunoglobulins (Igs) are antibodies that mediate humoral immunity. IgM typically represents the initial antibody response to antigens, while IgG is involved in long-term immunity and immunological memory.
IgG and IgM are critical players in the immune response, and their presence in tumors can reflect either an active anti-tumor immune response or, in some cases, aberrant expression by tumor cells that may contribute to malignancy.
A high density of immune cells producing these antibodies generally correlates with improved prognosis, reflecting an effective immune reaction against the tumor.
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