Signal Transducer and Activator of Transcription 6 (STAT6) is a transcription factor well-known for its role in mediating the effects of cytokines such as interleukin-4 (IL-4) and interleukin-13 (IL-13). Its activation and subsequent nuclear translocation trigger transcription of target genes that regulate immune responses, cell proliferation, and differentiation.
-STAT6 expression and activation have been documented in various malignancies such as lymphomas, breast cancer, and certain gastrointestinal cancers.
-Elevated or constitutive activation of STAT6 in tumors has been associated with a poorer prognosis in some cancer types, potentially due to its roles in promoting survival, proliferation, and immune evasion.
It also affects the composition and function of immune infiltrates within the tumor. Through modulating cytokine expression profiles, activated STAT6 can lead to a microenvironment that favors Th2 responses and suppresses effective anti-tumor immunity.
This dual role—impacting both intrinsic tumor cell biology and the extrinsic immune context—complicates the interpretation of STAT6 as a prognostic marker.
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