Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is an enzyme that catalyzes the final step in proline biosynthesis by reducing pyrroline-5-carboxylate to proline. This enzyme plays an integral role in cellular metabolism and redox balance. In the context of cancer, PYCR1 has emerged as a notable factor, with its expression levels often correlating with tumor progression and patient prognosis.
-Numerous studies have found that PYCR1 is overexpressed in a variety of tumor types, including breast cancer, lung cancer, liver cancer, and others.
Elevated PYCR1 expression is thought to provide tumor cells with a survival advantage by contributing to anabolic metabolism and helping to mitigate oxidative stress.
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