Fibroblast Growth Factor Receptor 1 (FGFR1) is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors (FGFs) to initiate signaling cascades regulating cell proliferation, differentiation, migration, and survival. Aberrant FGFR1 signaling—caused by gene amplification, mutations, or overexpression—has been linked to various cancers and can influence prognosis.
-Abnormal FGFR1 expression (usually overexpression or gene amplification) is observed in a diverse range of cancers, including lung cancer (notably squamous cell carcinoma), breast cancer, and hematologic malignancies, among others.
-FGFR1 gene amplification or overexpression often correlates with enhanced mitogenic signaling, contributing to tumor cell proliferation and survival.
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