Glomerular filtration rate—is primarily a clinical measure of kidney function rather than a molecular marker expressed by tumor cells.
GFR as an Indicator of Overall Patient Health and Tolerance to Therapy
– GFR is routinely measured in patients with cancer, especially because many anticancer therapies (such as chemotherapy agents, targeted therapies, and immunotherapies) are renally excreted or can be nephrotoxic.
– Lower GFR has been linked with poorer outcomes in various cancer types (for example, in patients with metastatic cancers, hematologic malignancies, or those undergoing major surgery) because it can limit the dosing and administration of effective therapies.
– Poor kidney function (low GFR) may be an indicator of frailty or overall decreased organ reserve, which in turn can correlate with worse overall survival and increased mortality.
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