NXA7 belongs to the annexin family of calcium-dependent phospholipid-binding proteins.
– It is involved in membrane trafficking, exocytosis, and cellular signal transduction.
– Its functions also extend to maintaining membrane integrity and participating in the regulation of intracellular calcium levels.
– Studies have shown that ANXA7 can function as a tumor suppressor in certain contexts, where its expression is reduced in tumors relative to normal tissue.
– In several tumor types, particularly prostate, breast, and glioblastoma, lower ANXA7 expression has been associated with a more aggressive tumor phenotype and poorer overall prognosis.
– Loss or reduced expression of ANXA7 may correlate with advanced disease stage, higher rates of recurrence, and decreased survival.
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